Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

被引：13

作者：

Barbeau, Julie ^{[1
,4
]}

Lemiegre, Lok ^{[1
,4
]}

Quelen, Allan ^{[1
,4
]}

Malard, Virginie ^{[2
]}

Gao, Haifei ^{[2
]}

Goncalves, Cristine ^{[2
]}

Berchel, Mathieu ^{[3
,4
]}

Jaffres, Paul-Alain ^{[3
,4
]}

Pichon, Chantal ^{[2
]}

Midoux, Patrick ^{[2
]}

Benvegnu, Thierry ^{[1
,4
]}

机构：

[1] Ecole Natl Super Chim Rennes, CNRS, UMR 6226, 11 Allee Beaulieu,CS 50837, F-35708 Rennes 7, France

[2] Univ Orleans, CNRS, UPR 4301, Ctr Biophys Mol, Rue Charles Sadron,CS 80054, F-45071 Orleans, France

[3] Univ Brest, ScInBioS SFR148, CNRS, UMR 6521,CEMCA, Brest, France

[4] Univ Bretagne Loire, Rennes, France

来源：

CARBOHYDRATE RESEARCH | 2016年 / 435卷

关键词：

Archaeal trimannosyl lipid; Liposomes; Dendritic cell binding; Mannose receptor; DELIVERY-SYSTEMS; DRUG-DELIVERY; RECOGNITION; RECEPTORS; ARCHAEOSOMES; VACCINE; CELLS;

D O I：

10.1016/j.carres.2016.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An archaeal diether lipid possessing a tri-antenna of alpha-D-mannopyranoside linked via an oligoethylene spacer to a (2S)-2-(phytanyloxy)-3-(hexadecyloxy)propanoic acid backbone (TriMan-Diether) was designed and synthesized. This new mannosylated lipid inserted in liposomes would show both DC-targeting and adjuvant properties thanks to the TriMan structure and the diether tail part, respectively. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：142 / 148

页数：7

共 31 条

[1] Optimizing saccharide-directed molecular delivery to biological receptors:: Design, synthesis, and biological evaluation of glycodendrimer -: Cyclodextrin conjugates [J].