The temporal dynamics of Plasmodium density through the sporogonic cycle within Anopheles mosquitoes

被引：15

作者：

Dawes, Emma J. ^{[1
]}

Zhuang, Shijie ^{[1
]}

Sinden, Robert E. ^{[2
]}

Basanez, Maria-Gloria ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Infect Dis Epidemiol, London W2 1PG, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Fac Life Sci, London SW7 2AZ, England

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 103卷 / 12期

基金：

英国医学研究理事会;

关键词：

Plasmodium; Anopheles; Transmission; Temporal dynamics; Parasite density; Sporogony;

D O I：

10.1016/j.trstmh.2009.03.009

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The impact of parasite density on malaria transmission remains unclear. We investigated sporogony temporal dynamics and the effect of parasite density on these dynamics. A series of experiments was conducted in which cages of mosquitoes were fed on blood containing a range of ookinete densities. Samples of surviving mosquitoes were dissected over time post-feeding to count oocyst and sporozoite numbers. Results reveal a humped (convex) pattern of oocyst numbers and suggest that transition rates between sporogony stages are density dependent. This has implications for the design of parasite-mosquito interface studies and the development of transmission-blocking strategies. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：1197 / 1198

页数：2

共 3 条

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Mendoza, Jacqui ;

Butcher, Geoff A. ;

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[2]

Sinden Robert E, 2002, Methods Mol Med, V72, P25, DOI 10.1385/1-59259-271-6:25

[3] Population dynamics of Plasmodium sporogony [J].

Vaughan, Jefferson A. .

TRENDS IN PARASITOLOGY, 2007, 23 (02) :63-70

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