Spatiotemporal specificity of synaptic plasticity: cellular rules and mechanisms

被引：63
作者：
Bi, GQ [1 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15261 USA
来源：
BIOLOGICAL CYBERNETICS | 2002年 / 87卷 / 5-6期
关键词：
D O I：
10.1007/s00422-002-0349-7
中图分类号：
TP3 [计算技术、计算机技术];
学科分类号：
0812 ;
摘要：
Recent experimental results on spike-timing-dependent plasticity (STDP) and heterosynaptic interaction in various systems have revealed new temporal and spatial properties of activity-dependent synaptic plasticity. These results challenge the conventional understanding of Hebb's rule and raise intriguing questions regarding the fundamental processes of cellular signaling. In this article, I review these new findings that lead to formulation of a new set of cellular rules. Emphasis is on evaluating potential molecular and cellular mechanisms that may underlie the spike-timing window of STDP and different patterns of heterosynaptic modifications. I also highlight several unresolved issues, and suggest future lines of research.
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收藏
页码：319 / 332
页数：14
相关论文
共 146 条
[1]   Synaptic plasticity: taming the beast [J].
Abbott, L. F. ;
Nelson, Sacha B. .
NATURE NEUROSCIENCE, 2000, 3 (11) :1178-1183
[2]   Functional significance of long-term potentiation for sequence learning and prediction [J].
Abbott, LF ;
Blum, KI .
CEREBRAL CORTEX, 1996, 6 (03) :406-416
[3]   ASYMMETRIC RELATIONSHIPS BETWEEN HOMOSYNAPTIC LONG-TERM POTENTIATION AND HETEROSYNAPTIC LONG-TERM DEPRESSION [J].
ABRAHAM, WC ;
GODDARD, GV .
NATURE, 1983, 305 (5936) :717-719
[4]   SPECIFIC LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN HIPPOCAMPAL SLICES [J].
ANDERSEN, P ;
SUNDBERG, SH ;
SVEEN, O ;
WIGSTROM, H .
NATURE, 1977, 266 (5604) :736-737
[5]   LONG-TERM DEPRESSION OF EXCITATORY SYNAPTIC TRANSMISSION AND ITS RELATIONSHIP TO LONG-TERM POTENTIATION [J].
ARTOLA, A ;
SINGER, W .
TRENDS IN NEUROSCIENCES, 1993, 16 (11) :480-487
[6]   Toward a molecular definition of long-term memory storage [J].
Bailey, CH ;
Bartsch, D ;
Kandel, ER .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13445-13452
[7]  
Bear Mark F., 1994, Current Opinion in Neurobiology, V4, P389, DOI 10.1016/0959-4388(94)90101-5
[8]   Long-term depression in hippocampus [J].
Bear, MF ;
Abraham, WC .
ANNUAL REVIEW OF NEUROSCIENCE, 1996, 19 :437-462
[9]   Synaptic plasticity in a cerebellum-like structure depends on temporal order [J].
Bell, CC ;
Han, VZ ;
Sugawara, Y ;
Grant, K .
NATURE, 1997, 387 (6630) :278-281
[10]   Synaptic modification in neural circuits: a timely action [J].
Berninger, B ;
Bi, GQ .
BIOESSAYS, 2002, 24 (03) :212-222
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