Complement Activation by Polymers Carrying Hydroxyl Groups

被引：42

作者：

Arima, Yusuke ^{[1
]}

Kawagoe, Masako ^{[1
]}

Toda, Mitsuaki ^{[1
,2
]}

Iwata, Hiroo ^{[1
]}

机构：

[1] Kyoto Univ, Inst Frontier Med Sci, Sakyo Ku, Kyoto 6068507, Japan

[2] Adv Software Technol & Mechatron Res Inst Kyoto, Shimogyo Ku, Kyoto 6008813, Japan

来源：

ACS APPLIED MATERIALS & INTERFACES | 2009年 / 1卷 / 10期

关键词：

complement activation; protein adsorption; poly(vinyl alcohol); dextran; SELF-ASSEMBLED MONOLAYERS; HEMODIALYSIS MEMBRANES; PROVIDES INSIGHTS; PATHWAY; POLYSACCHARIDE; IMMOBILIZATION; NANOPARTICLES; C3B; SEPHADEX;

D O I：

10.1021/am9005463

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Hydrogels of polymers carrying Surface hydroxyl groups strongly activate the complement system through the alternative pathway, although it has also been reported that solutions of polymers do not. To address these curious, inconsistent results. we examined the effect of polymer states, either immobilized on a surface or soluble in serum, on the complement activation using a surface plasmon resonance apparatus and enzyme-linked immunosorbent assay We clearly showed that dextran- and poly(vinyl alcohol)-immobilized surfaces strongly activated the complement system but that soluble polymers could not, even when the amounts of the soluble polymers added to serum were 4-2000 dines higher than those on the polymer-immobilized surfaces

引用

页码：2400 / 2407

页数：8

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