Scanning fiber angle-resolved low coherence interferometry

被引:12
|
作者
Zhu, Yizheng [1 ]
Terry, Neil G. [1 ]
Wax, Adam [1 ]
机构
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
基金
美国国家卫生研究院;
关键词
SCATTERING SPECTROSCOPY; CANCER; CELLS;
D O I
10.1364/OL.34.003196
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We present a fiber-optic probe for Fourier-domain angle-resolved low coherence interferometry for the determination of depth-resolved scatterer size. The probe employs a scanning single-mode fiber to collect the angular scattering distribution of the sample, which is analyzed using the Mie theory to obtain the average size of the scatterers. Depth sectioning is achieved with low coherence Mach-Zehnder interferometry. In the sample arm of the interferometer, a fixed fiber illuminates the sample through an imaging lens and a collection fiber samples the backscattered angular distribution by scanning across the Fourier plane image of the sample. We characterize the optical performance of the probe and demonstrate the ability to execute depth-resolved sizing with subwavelength accuracy by using a double-layer phantom containing two sizes of polystyrene microspheres. (C) 2009 Optical Society of America
引用
收藏
页码:3196 / 3198
页数:3
相关论文
共 50 条
  • [1] Scanning fiber system for angle-resolved low coherence interferometry
    Zhu, Yizheng
    Terry, Neil G.
    Giacomelli, Michael G.
    Wax, Adam
    BIOMEDICAL APPLICATIONS OF LIGHT SCATTERING IV, 2010, 7573
  • [2] Scanning system for angle-resolved low-coherence interferometry
    Steelman, Zachary A.
    Ho, Derek
    Chu, Kengyeh K.
    Wax, Adam
    OPTICS LETTERS, 2017, 42 (22) : 4581 - 4584
  • [3] Prospective detection of cervical dysplasia with scanning angle-resolved low coherence interferometry
    Kendall, Wesley Y.
    Ho, Derek
    Chu, Kengyeh
    Zinaman, Michael
    Wieland, Daryl
    Moragne, Kandis
    Wax, Adam
    BIOMEDICAL OPTICS EXPRESS, 2020, 11 (09) : 5197 - 5211
  • [4] Rapid angle-resolved low coherence interferometry measurements
    Pyhtila, JW
    Wax, A
    Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, 2005, 5690 : 468 - 474
  • [5] Detection of intestinal dysplasia using angle-resolved low coherence interferometry
    Terry, Neil
    Zhu, Yizheng
    Thacker, Julie K. M.
    Migaly, John
    Guy, Cynthia
    Mantyh, Christopher R.
    Wax, Adam
    JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (10)
  • [6] Detection of Intestinal Dysplasia Using Angle-Resolved Low Coherence Interferometry
    Terry, Neil G.
    Zhu, Yizheng
    Guy, Cynthia D.
    Migaly, John
    Thacker, Julie K.
    Mantyh, Christopher R.
    Wax, Adam
    GASTROENTEROLOGY, 2010, 138 (05) : S666 - S666
  • [7] DETECTION OF INTESTINAL DYSPLASIA USING ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY
    Mantyh, C.
    Terry, N.
    Zhu, Y.
    Wax, A.
    Guy, C.
    Migaly, J.
    Thacker, J.
    DISEASES OF THE COLON & RECTUM, 2010, 53 (04) : 531 - 533
  • [8] Angle-resolved three-dimensional analysis of surface films by coherence scanning interferometry
    de Groot, Peter
    Colonna de Lega, Xavier
    OPTICS LETTERS, 2007, 32 (12) : 1638 - 1640
  • [9] Detection of Dysplasia in Barrett's Esophagus with Angle-Resolved Low Coherence Interferometry
    Wax, Adam
    Terry, Neil G.
    Zhu, Yizheng
    Gebhart, Steven C.
    Brown, William J.
    Bright, Stehanie D.
    Carretta, Elizabeth E.
    Woosley, John T.
    Shaheen, Nicholas J.
    GASTROENTEROLOGY, 2009, 136 (05) : A592 - A592
  • [10] Detection of Dysplasia in Barrett's Esophagus With Angle-Resolved Low Coherence Interferometry
    Terry, Neil G.
    Zhu, Yizheng
    Gebhart, Steven C.
    Brown, William J.
    Bright, Stephanie D.
    Ziefle, Courtney
    Woosley, John T.
    Shaheen, Nicholas J.
    Wax, Adam
    GASTROINTESTINAL ENDOSCOPY, 2010, 71 (05) : AB121 - AB122