An ultrasensitive electrochemiluminescence biosensor for nuclear factor kappa B p50 based on the proximity hybridization-induced hybridization chain reaction

被引：23

作者：

Huang, Xiaocui ^{[1
]}

Zhang, Ying ^{[1
]}

Xu, Wen ^{[2
]}

Xu, Wei ^{[2
]}

Guo, Longhua ^{[1
]}

Qiu, Bin ^{[1
]}

Lin, Zhenyu ^{[1
]}

机构：

[1] Fuzhou Univ, Fujian Prov Key Lab Anal & Detect Food Safety, Key Lab Analyt Sci Food Safety & Biol, Minist Educ,Coll Chem, Fuzhou 350116, Fujian, Peoples R China

[2] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350122, Fujian, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 86期

基金：

中国国家自然科学基金;

关键词：

ELECTROGENERATED CHEMILUMINESCENCE; TRANSCRIPTION FACTORS; AMPLIFICATION; DNA; APTASENSOR; PROTEIN; SIGNAL;

D O I：

10.1039/c9cc06210f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nuclear factor kappa B p50 (NF-kappa B p50) induces various biological processes. In this study, a highly selective and sensitive electrochemiluminescence (ECL) biosensor for the detection of NF-kappa B p50 has been developed, which combines the high selectivity of the proximity hybridization assay (PHA) with the high efficiency of the hybridization chain reaction (HCR).

引用

页码：12980 / 12983

页数：4

共 24 条

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Bard A.J., 2001, ELECTROCHEMICAL METH, V2, P482, DOI DOI 10.1016/J.ELECTACTA.2009.09.020

[2]

Bard A.J., 2004, Electrogenerated Chemiluminescence

[3] NF-κB family of transcription factors:: Central regulators of innate and adaptive immune functions [J].