Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever

被引:147
作者
Naess, Are [1 ]
Nilssen, Siri Saervold [1 ,2 ]
Mo, Reidun [1 ,2 ]
Eide, Geir Egil [3 ,4 ]
Sjursen, Haakon [1 ,2 ]
机构
[1] Univ Bergen, Dept Clin Sci, Haukeland Univ Hosp, N-5021 Bergen, Norway
[2] Haukeland Hosp, Dept Med, Bergen, Norway
[3] Haukeland Hosp, Ctr Clin Res, Bergen, Norway
[4] Univ Bergen, Dept Global Publ Hlth & Primary Care, Lifestyle Epidemiol Res Grp, Bergen, Norway
关键词
Fever; Infections; Neutrophil: lymphocyte ratio (NLR); Monocyte: lymphocyte ratio (MLR); PERIPHERAL-BLOOD; COLORECTAL-CANCER; PROGNOSTIC MARKER; TUBERCULOSIS; METAANALYSIS; MORTALITY; IMPROVES; RISK;
D O I
10.1007/s15010-016-0972-1
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
To study the role of the neutrophil:lymphocyte ratio (NLR) and monocyte:lymphocyte ratio (MLR) in discriminating between different patient groups hospitalized for fever due to infection and those without infection. For 299 patients admitted to hospital for fever with unknown cause, a number of characteristics including NLR and MLR were recorded. These characteristics were used in a multiple multinomial regression analysis to estimate the probability of a final diagnostic group of bacterial, viral, clinically confirmed, or no infection. Both NLR and MLR significantly predicted final diagnostic group. Being highly correlated, however, both variables could not be retained in the same model. Both variables also interacted significantly with duration of fever. Generally, higher values of NLR and MLR indicated larger probabilities for bacterial infection and low probabilities for viral infection. Patients with septicemia had significantly higher NLR compared to patients with other bacterial infections with fever for less than one week. White blood cell counts, neutrophil counts, and C-reactive proteins did not differ significantly between septicemia and the other bacterial infection groups. NLR is a more useful diagnostic tool to identify patients with septicemia than other more commonly used diagnostic blood tests. NLR and MLR may be useful in the diagnosis of bacterial infection among patients hospitalized for fever.
引用
收藏
页码:299 / 307
页数:9
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