Rh(III)-catalyzed C-H activation-desymmetrization of diazabicycles using enol as directing group: A straightforward approach to difunctionalized cyclopentenes

被引：3
|
作者：
Zhang, Yan [1 ]
Shang, Tianbo [1 ]
Li, Lisha [1 ]
He, Yu [1 ]
Wen, Tingting [1 ]
Tu, Yanan [1 ]
Wang, Shanshan [1 ]
Lin, Dan [1 ]
机构：
[1] Zhejiang Normal Univ, Dept Chem, Key Lab, Minist Educ Adv Catalysis Mat, 688 Yingbin Rd, Jinhua 321004, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Rh(III)-catalysis; C-H activation; Cyclopentene; Enol; Desymmetrization; MESO-BICYCLIC HYDRAZINES; CATALYZED OXIDATIVE ANNULATION; ONE-POT STRATEGY; ENANTIOSELECTIVE DESYMMETRIZATION; FACILE SYNTHESIS; BOND FORMATION; N BOND; ACCESS; ALKYNES; FUNCTIONALIZATION;
D O I：
10.1016/j.tetlet.2018.02.063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Rh(III)-catalyzed C-H activation-desymmetrization of diazabicycles with o-vinylphenols as an efficient approach to alkenyl-substituted aminocyclopentenes is reported. This protocol represents another classic example for direct C-H activation of terminal alkenes using enol as directing group. The reaction features the ease of the preparation of starting materials, fast and high efficiency, broad substrate scope and 100% atom economy, thus provides a valuable entry to synthesize novel substituted cyclopentenes. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1394 / 1397
页数：4
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