Rh(III)-catalyzed C-H activation-desymmetrization of diazabicycles using enol as directing group: A straightforward approach to difunctionalized cyclopentenes

被引：3

作者：

Zhang, Yan ^{[1
]}

Shang, Tianbo ^{[1
]}

Li, Lisha ^{[1
]}

He, Yu ^{[1
]}

Wen, Tingting ^{[1
]}

Tu, Yanan ^{[1
]}

Wang, Shanshan ^{[1
]}

Lin, Dan ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Dept Chem, Key Lab, Minist Educ Adv Catalysis Mat, 688 Yingbin Rd, Jinhua 321004, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Rh(III)-catalysis; C-H activation; Cyclopentene; Enol; Desymmetrization; MESO-BICYCLIC HYDRAZINES; CATALYZED OXIDATIVE ANNULATION; ONE-POT STRATEGY; ENANTIOSELECTIVE DESYMMETRIZATION; FACILE SYNTHESIS; BOND FORMATION; N BOND; ACCESS; ALKYNES; FUNCTIONALIZATION;

D O I：

10.1016/j.tetlet.2018.02.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(III)-catalyzed C-H activation-desymmetrization of diazabicycles with o-vinylphenols as an efficient approach to alkenyl-substituted aminocyclopentenes is reported. This protocol represents another classic example for direct C-H activation of terminal alkenes using enol as directing group. The reaction features the ease of the preparation of starting materials, fast and high efficiency, broad substrate scope and 100% atom economy, thus provides a valuable entry to synthesize novel substituted cyclopentenes. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1394 / 1397

页数：4

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