Probing the Motion of the Intrinsically Disordered Neuronal Protein Alpha-Synuclein through the VDAC Pore using a Single-Molecule Approach

被引:0
|
作者
Hoogerheide, David P. [1 ,2 ]
Gurnev, Philip A. [1 ,3 ]
Rostovtseva, Tatiana K. [1 ]
Bezrukov, Sergey M. [1 ]
机构
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA
[2] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA
[3] Univ Massachusetts, Dept Phys, Amherst, MA 01003 USA
关键词
D O I
10.1016/j.bpj.2014.11.1025
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
933-Plat
引用
收藏
页码:185A / 185A
页数:1
相关论文
共 50 条
  • [11] Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates
    Chappard, Alexandre
    Leighton, Craig
    Saleeb, Rebecca S.
    Jeacock, Kiani
    Ball, Sarah R.
    Morris, Katie
    Kantelberg, Owen
    Lee, Ji-Eun
    Zacco, Elsa
    Pastore, Annalisa
    Sunde, Margaret
    Clarke, David J.
    Downey, Patrick
    Kunath, Tilo
    Horrocks, Mathew H.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 62 (15)
  • [12] Insights into the conformations and dynamics of intrinsically disordered proteins using single-molecule fluorescence
    Gomes, Gregory-Neal
    Gradinaru, Claudiu C.
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2017, 1865 (11): : 1696 - 1706
  • [13] Conformational Ensembles of an Intrinsically Disordered Protein Consistent with NMR, SAXS, and Single-Molecule FRET
    Gomes, Gregory-Neal W.
    Krzeminski, Mickael
    Namini, Ashley
    Martin, Erik W.
    Mittag, Tanja
    Head-Gordon, Teresa
    Forman-Kay, Julie D.
    Gradinaru, Claudiu C.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 142 (37) : 15697 - 15710
  • [14] Discrimination between Alpha-Synuclein Protein Variants with a Single Nanometer-Scale Pore
    Bakshloo, Mazdak Afshar
    Yahiaoui, Safia
    Bourderioux, Matthieu
    Daniel, Regis
    Pastoriza-Gallego, Manuela
    Kasianowicz, John J.
    Oukhaled, Abdelghani
    ACS CHEMICAL NEUROSCIENCE, 2023, 14 (14): : 2517 - 2526
  • [15] Quantitative Description of Intrinsically Disordered Proteins Using Single-Molecule FRET, NMR, and SAXS
    Naudi-Fabra, Samuel
    Tengo, Maud
    Jensen, Malene Ringkjobing
    Blackledge, Martin
    Milles, Sigrid
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 143 (48) : 20109 - 20121
  • [16] Single-Molecule Studies of Intrinsically Disordered Proteins Using Solid-State Nanopores
    Japrung, Deanpen
    Dogan, Jakob
    Freedman, Kevin.
    Nadzeyka, Achim
    Bauerdick, Sven
    Albrecht, Tim
    Kim, Min Jun
    Jemth, Per
    Edel, Joshua B.
    ANALYTICAL CHEMISTRY, 2013, 85 (04) : 2449 - 2456
  • [17] Single-Molecule FRET Probes a Transient Complex that Facilitates Binding of an Intrinsically-Disordered Protein
    Kim, Jae-Yeol
    Meng, Fanjie
    Chung, Hoi Sung
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 209A - 209A
  • [18] Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
    Laura Tosatto
    Mathew H. Horrocks
    Alexander J. Dear
    Tuomas P. J. Knowles
    Mauro Dalla Serra
    Nunilo Cremades
    Christopher M. Dobson
    David Klenerman
    Scientific Reports, 5
  • [19] Single-Molecule FRET Reveals Shifting Folding Landscapes for Parkinson's-Related Alpha-Synuclein
    Moran, Crystal R.
    Deniz, Ashok A.
    BIOPHYSICAL JOURNAL, 2011, 100 (03) : 184 - 184
  • [20] Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants
    Tosatto, Laura
    Horrocks, Mathew H.
    Dear, Alexander J.
    Knowles, Tuomas P. J.
    Dalla Serra, Mauro
    Cremades, Nunilo
    Dobson, Christopher M.
    Klenerman, David
    SCIENTIFIC REPORTS, 2015, 5