Structures of Class B G Protein-Coupled Receptors: Prospects for Drug Discovery

被引：7
作者：
Hausch, Felix [1 ]
机构：
[1] Max Planck Inst Psychiat, AG Chem Genom, D-80804 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 49期
关键词：
drug design; GPCRs; glucagon; receptors; structure elucidation; BINDING-KINETICS; NOBEL LECTURE; PEPTIDE; PHARMACOLOGY;
D O I：
10.1002/anie.201307542
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New members in the GPCR photo gallery! Crystal structures of class B G protein-coupled receptors, which bind peptide hormones, have been solved [see picture of the corticotropin-releasing factor receptor 1 (blue) and a bound allosteric nonpeptide antagonist (green)]. The structures provide a basis for a rational design of better drugs for diabetes, osteoporosis, migraine, or depression. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12783 / 12785
页数：3
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