Covid-19, Angiogenesis, and ARDS Endotypes

被引：64

作者：

Hariri, Lida ^{[1
]}

Hardin, C. Corey ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 383卷 / 02期

关键词：

RESPIRATORY-DISTRESS-SYNDROME;

D O I：

10.1056/NEJMe2018629

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The SARS-CoV-2 pandemic has inspired new interest in understanding the fundamental pathology of acute respiratory distress syndrome (ARDS), which has been associated with severe coronavirus disease 2019 (Covid-19). ARDS has long been recognized to be remarkably heterogeneous, with not only a wide range of causes but also a broad spectrum of severity, abnormalities on imaging, and gas-exchange impairment.(1) The form of ARDS that is associated with Covid-19 is no different.(2) A long-standing goal(3) has been to define endotypes that subdivide ARDS into groups on the basis of distinct biologic and pathologic processes in order to design higher-yield clinical trials and . . .

引用

页码：182 / 183

页数：2

共 9 条

[1] Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 [J].

Ackermann, Maximilian ;

Verleden, Stijn E. ;

Kuehnel, Mark ;

Haverich, Axel ;

Welte, Tobias ;

Laenger, Florian ;

Vanstapel, Arno ;

Werlein, Christopher ;

Stark, Helge ;

Tzankov, Alexandar ;

Li, William W. ;

Li, Vincent W. ;

Mentzer, Steven J. ;

Jonigk, Danny .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (02) :120-128

[2] Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries [J].

Bellani, Giacomo ;

Laffey, John G. ;

Pham, Tai ;

Fan, Eddy ;

Brochard, Laurent ;

Esteban, Andres ;

Gattinoni, Luciano ;

van Haren, Frank ;

Larsson, Anders ;

McAuley, Daniel F. ;

Ranieri, Marco ;

Rubenfeld, Gordon ;

Thompson, B. Taylor ;

Wrigge, Hermann ;

Slutsky, Arthur S. ;

Pesenti, Antonio .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (08) :788-800

[3] Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. [J].

Brower, RG ;

Matthay, MA ;

Morris, A ;

Schoenfeld, D ;

Thompson, BT ;

Wheeler, A ;

Wiedemann, HP ;

Arroliga, AC ;

Fisher, CJ ;

Komara, JJ ;

Perez-Trepichio, P ;

Parsons, PE ;

Wolkin, R ;

Welsh, C ;

Fulkerson, WJ ;

MacIntyre, N ;

Mallatratt, L ;

Sebastian, M ;

McConnell, R ;

Wilcox, C ;

Govert, J ;

Thompson, D ;

Clemmer, T ;

Davis, R ;

Orme, J ;

Weaver, L ;

Grissom, C ;

Eskelson, M ;

Young, M ;

Gooder, V ;

McBride, K ;

Lawton, C ;

d'Hulst, J ;

Peerless, JR ;

Smith, C ;

Brownlee, J ;

Pluss, W ;

Kallet, R ;

Luce, JM ;

Gottlieb, J ;

Elmer, M ;

Girod, A ;

Park, P ;

Daniel, B ;

Gropper, M ;

Abraham, E ;

Piedalue, F ;

Glodowski, J ;

Lockrem, J ;

McIntyre, R .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (18) :1301-1308

[4]

Gattinoni LCD, 2020, INTENSIVE CARE MED

[5] Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy [J].

Grasselli, Giacomo ;

Zangrillo, Alberto ;

Zanella, Alberto ;

Antonelli, Massimo ;

Cabrini, Luca ;

Castelli, Antonio ;

Cereda, Danilo ;

Coluccello, Antonio ;

Foti, Giuseppe ;

Fumagalli, Roberto ;

Iotti, Giorgio ;

Latronico, Nicola ;

Lorini, Luca ;

Merler, Stefano ;

Natalini, Giuseppe ;

Piatti, Alessandra ;

Ranieri, Marco Vito ;

Scandroglio, Anna Mara ;

Storti, Enrico ;

Cecconi, Maurizio ;

Pesenti, Antonio .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1574-1581

[6] PULMONARY VASCULAR OBSTRUCTION IN SEVERE ARDS - ANGIOGRAPHIC ALTERATIONS AFTER IV-FIBRINOLYTIC THERAPY [J].

GREENE, R ;

LIND, S ;

JANTSCH, H ;

WILSON, R ;

LYNCH, K ;

JONES, R ;

CARVALHO, A ;

REID, L ;

WALTMAN, AC ;

ZAPOL, W .

AMERICAN JOURNAL OF ROENTGENOLOGY, 1987, 148 (03) :501-508

[7] Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care [J].

Iwashyna, Theodore J. ;

Burke, James F. ;

Sussman, Jeremy B. ;

Prescott, Hallie C. ;

Hayward, Rodney A. ;

Angus, Derek C. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 192 (09) :1045-1051

[8] Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design [J].

Prescott, Hallie C. ;

Calfee, Carolyn S. ;

Thompson, B. Taylor ;

Angus, Derek C. ;

Liu, Vincent X. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 194 (02) :147-155

[9] Plasma Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis [J].

Terpstra, Matty L. ;

Aman, Jurjan ;

Amerongen, Geerten P. van Nieuw ;

Groeneveld, A. B. Johan .

CRITICAL CARE MEDICINE, 2014, 42 (03) :691-700

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