Delayed treatment with nicotinamide (vitamin B3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats

被引：37
作者：
Sakakibara, Y
Mitha, AP
Ayoub, IA
Ogilvy, CS
Maynard, KI
机构：
[1] Massachusetts Gen Hosp, Neurosurg Serv, Neurophysiol Lab, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
来源：
BRAIN RESEARCH | 2002年 / 931卷 / 01期
关键词：
neuroprotection; niacinamide; stroke; Poly(ADP ribose polymerase inhibitor; hypertension; diabetes;
D O I：
10.1016/S0006-8993(02)02263-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo). Intravenous NAm given 2 h after MCAo significantly reduced the infarct volume of SHR (750 mg/kg, 31%, P<0.01) and diabetic (500 mg/kg, 56%, P<0.01) as well as non-diabetic (500 mg/kg, 73%, P<0.01) Fischer 344 rats when compared with saline-injected controls. Thus delayed treatment with NAm protected hypertensive and hyperglycemic rats against a robust model of stroke. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：68 / 73
页数：6
相关论文
共 45 条
[11]   Genetic and gender influences on sensitivity to focal cerebral ischemia in the stroke-prone spontaneously hypertensive rat [J].
Carswell, HVO ;
Anderson, NH ;
Clark, JS ;
Graham, D ;
Jeffs, B ;
Dominiczak, AF ;
Macrae, IM .
HYPERTENSION, 1999, 33 (02) :681-685
[12]   DIFFERENT SUSCEPTIBILITIES TO CEREBRAL INFARCTION IN SPONTANEOUSLY HYPERTENSIVE (SHR) AND NORMOTENSIVE SPRAGUE-DAWLEY RATS [J].
COYLE, P .
STROKE, 1986, 17 (03) :520-525
[13]   Temporal impairment of microcirculatory perfusion following focal cerebral ischemia in the spontaneously hypertensive rat [J].
Dawson, DA ;
Ruetzler, CA ;
Hallenbeck, JM .
BRAIN RESEARCH, 1997, 749 (02) :200-208
[14]  
Dogan A, 1998, NEUROL RES, V20, P265
[15]   Protective effects of memantine against ischemia-reperfusion injury in Spontaneously Hypertensive Rats [J].
Dogan, A ;
Eras, MA ;
Rao, VLR ;
Dempsey, RJ .
ACTA NEUROCHIRURGICA, 1999, 141 (10) :1107-1113
[16]   THE QUANTIFICATION OF CEREBRAL INFARCTION FOLLOWING FOCAL ISCHEMIA IN THE RAT - INFLUENCE OF STRAIN, ARTERIAL-PRESSURE, BLOOD-GLUCOSE CONCENTRATION, AND AGE [J].
DUVERGER, D ;
MACKENZIE, ET .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (04) :449-461
[17]   Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase [J].
Endres, M ;
Wang, ZQ ;
Namura, S ;
Waeber, C ;
Moskowitz, MA .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (11) :1143-1151
[18]   RODENT MODELS OF CEREBRAL-ISCHEMIA [J].
GINSBERG, MD ;
BUSTO, R .
STROKE, 1989, 20 (12) :1627-1642
[19]   Acute treatment of hypertension increases infarct sizes in spontaneously hypertensive rats [J].
Harms, H ;
Wiegand, F ;
Megow, D ;
Prass, K ;
Einhäupl, KM ;
Dirnagl, U .
NEUROREPORT, 2000, 11 (02) :355-359
[20]   NICOTINAMIDE PHARMACOKINETICS IN HUMANS AND MICE - A COMPARATIVE-ASSESSMENT AND THE IMPLICATIONS FOR RADIOTHERAPY [J].
HORSMAN, MR ;
HOYER, M ;
HONESS, DJ ;
DENNIS, IF ;
OVERGAARD, J .
RADIOTHERAPY AND ONCOLOGY, 1993, 27 (02) :131-139
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