Delayed treatment with nicotinamide (vitamin B3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats

被引：37
作者：
Sakakibara, Y
Mitha, AP
Ayoub, IA
Ogilvy, CS
Maynard, KI
机构：
[1] Massachusetts Gen Hosp, Neurosurg Serv, Neurophysiol Lab, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
来源：
BRAIN RESEARCH | 2002年 / 931卷 / 01期
关键词：
neuroprotection; niacinamide; stroke; Poly(ADP ribose polymerase inhibitor; hypertension; diabetes;
D O I：
10.1016/S0006-8993(02)02263-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo). Intravenous NAm given 2 h after MCAo significantly reduced the infarct volume of SHR (750 mg/kg, 31%, P<0.01) and diabetic (500 mg/kg, 56%, P<0.01) as well as non-diabetic (500 mg/kg, 73%, P<0.01) Fischer 344 rats when compared with saline-injected controls. Thus delayed treatment with NAm protected hypertensive and hyperglycemic rats against a robust model of stroke. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：68 / 73
页数：6
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