Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ

被引:74
作者
Haranahalli, Krupanandan [1 ]
Tong, Simon [1 ]
Ojima, Iwao [1 ,2 ]
机构
[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Inst Chem Biol & Drug Discovery, Stony Brook, NY 11794 USA
基金
美国国家卫生研究院;
关键词
Antibacterial agent; Multidrug resistance; FtsZ; Z-ring protofilament; Septation; Cell division; Inhibitor; INHIBITS BACTERIAL PROLIFERATION; ANTIMICROBIAL PEPTIDE CRAMP; ESCHERICHIA-COLI; MYCOBACTERIUM-TUBERCULOSIS; BACILLUS-SUBTILIS; IN-VITRO; Z-RING; PROPER PLACEMENT; FORCE GENERATION; DRUG DISCOVERY;
D O I
10.1016/j.bmc.2016.05.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug targets for antibacterial drug discovery and development. Filamentous temperature sensitive protein Z (FtsZ), is a GTP-dependent prokaryotic cell division protein, sharing less than 10% sequence identity with the eukaryotic cell division protein, tubulin. FtsZ forms a dynamic Z-ring in the middle of the cell, leading to septation and subsequent cell division. Inhibition of the Z-ring blocks cell division, thus making FtsZ a highly attractive target. Various groups have been working on natural products and synthetic small molecules as inhibitors of FtsZ. This review summarizes the recent advances in the development of FtsZ inhibitors, focusing on those in the last 5 years, but also includes significant findings in previous years. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:6354 / 6369
页数:16
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