Resonance light-scattering method for the determination of labetalol using uranyl acetate and aniline blue

被引：7
作者：
Sun, Qian [1 ]
Jiang, Xianchen [1 ]
Ma, Jing [1 ]
Anzai, Jun-ichi [2 ]
Wang, Baozhen [2 ]
Du, Xiaoyan [1 ]
机构：
[1] Harbin Med Univ, Coll Publ Hlth, Harbin 150081, Peoples R China
[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sandai 9808578, Japan
来源：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2009年 / 29卷 / 01期
关键词：
Labetalol; Aniline blue; Uranyl acetate; Resonance light-scattering; Human urine; PERFORMANCE LIQUID-CHROMATOGRAPHY; BETA-BLOCKERS; SPECTROFLUOROMETRIC DETERMINATION; PLASMA; URINE;
D O I：
10.1016/j.msec.2008.06.021
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A sensitive and convenient method for determining labetalol has been developed based on resonance light-scattering using ternary complex of aniline blue (AB), uranyl ion (UO22+) and labetalol. At pH 6.0-7.0, labetalol reacted with AB and UO22+ to form an ion-association complex that resulted in considerable resonance light-scattering (RLS) characterized with a peak at 356 nm. The RLS was successfully applied to the determination of labetalol. The intensity of RLS (I-RLS) at 356 nm linearly depended on the concentration of labetalol ranging from 4.0 x 10(-7) to 2.4 x 10(-4) mol L-1. The lower detection limit was 2.1 x 10(-7) mol L-1. The present method is highly selective to labetalol and can successfully be applied to the determination of labetalol in human urine. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：271 / 274
页数：4
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