Two New Flavones from Salvia plebeia and Their Anti-Angiogenic Activities

被引：0
|
作者：
Ma, Qinge [1 ]
Wei, Rongrui [1 ]
Lu, Qixin [1 ]
Huang, Haofeng [1 ]
Guo, Dongmei [1 ]
Jiang, Lin [1 ]
机构：
[1] Jiangxi Univ Tradit Chinese Med, Res Ctr Nat Resources Chinese Med Mat & Ethn Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2020年 / 56卷 / 06期
关键词：
Salvia plebeia; flavone; anti-angiogenic activity; SESQUITERPENOIDS; DERIVATIVES;
D O I：
10.1007/s10600-020-03218-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new flavones, namely 5-hydroxy-2-(4 '-hydroxyphenyl)-6,12,13-trimethoxypyrano-xanthene-4,9-dione (1) and 5-hydroxy-2-(3 '-methoxy-4 '-hydroxyphenyl)-6-methoxy-11-isopropyl-pyranochromene-4,9-dione (2), were isolated from Salvia plebeia. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR spectral data. Compounds 1 and 2 were evaluated for their anti-angiogenic activities by the MTT assay with axitinib as positive control, and they displayed moderate anti-angiogenic activities with IC50 values of 14.07 and 11.25 mu M, respectively.
引用
收藏
页码：1019 / 1022
页数：4
相关论文
共 50 条
  • [41] Anti-angiogenic activities of hypericin in vivo: Potential for ophthalmologic applications
    Lavie G.
    Mandel M.
    Hazan S.
    Barliya T.
    Blank M.
    Grunbaum A.
    Meruelo D.
    Solomon A.
    Angiogenesis, 2005, 8 (1) : 35 - 42
  • [42] Anti-angiogenic activities of Cnidium officinale Makino and Tabanus bovinus
    Kwak, DH
    Kim, JK
    Kim, JY
    Jeong, HY
    Keum, KS
    Han, SH
    Rho, YI
    Woo, WH
    Jung, KY
    Choi, BK
    Choo, YK
    JOURNAL OF ETHNOPHARMACOLOGY, 2002, 81 (03) : 373 - 379
  • [43] Comparison of anti-angiogenic activities of thalidomide and lenalidomide in vitro.
    Zhang, LH
    Lu, L
    Wu, L
    Dredge, K
    Bartlett, JB
    Schafer, P
    Muller, G
    Dalgleish, A
    Stirling, D
    BLOOD, 2005, 106 (11) : 69B - 69B
  • [44] In vitro antitumor and anti-angiogenic activities of a shrimp chondroitin sulfate
    Palhares, Lais C. G. F.
    Barbosa, Jefferson S.
    Scortecci, Katia C.
    Rocha, Hugo A. O.
    Brito, Adriana S.
    Chavante, Suely F.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 162 : 1153 - 1165
  • [45] Anti-angiogenic and anti-metastatic activities of juglone in pancreatic cancer cells
    Karki, Namrata
    Greenway, Frank
    Hansel, William
    Aggarwal, Sita
    Losso, Jack N.
    CANCER RESEARCH, 2016, 76
  • [46] In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs
    El-Aarag, Bishoy Y. A.
    Kasai, Tomonari
    Zahran, Magdy A. H.
    Zakhary, Nadia I.
    Shigehiro, Tsukasa
    Sekhar, Sreeja C.
    Agwa, Hussein S.
    Mizutani, Akifumi
    Murakami, Hiroshi
    Kakuta, Hiroki
    Seno, Masaharu
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2014, 21 (02) : 283 - 292
  • [47] Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells
    Cheng, JJ
    Huang, NK
    Chang, TT
    Wang, DL
    Lu, MK
    LIFE SCIENCES, 2005, 76 (26) : 3029 - 3042
  • [48] Anti-angiogenic, Anti-inflammatory and Anti-nociceptive Activities of Vanillyl Alcohol
    Jung, Hynn-Joo
    Song, Yun Seon
    Lim, Chang-Jin
    Park, Eun-Hee
    ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (10) : 1275 - 1279
  • [49] Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillyl alcohol
    Hyun-Joo Jung
    Yun Seon Song
    Chang-Jin Lim
    Eun-Hee Park
    Archives of Pharmacal Research, 2008, 31 : 1275 - 1279
  • [50] Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki
    Lecht, Shimon
    Chiaverelli, Rachel A.
    Gerstenhaber, Jonathan
    Calvete, Juan J.
    Lazarovici, Philip
    Casewell, Nicholas R.
    Harrison, Robert
    Lelkes, Peter I.
    Marcinkiewicz, Cezary
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2015, 1850 (06): : 1169 - 1179
12345