DNA repair by the MRN complex: Break it to make it

被引：28
作者：
Kanaar, Roland [1 ,2 ]
Wyman, Claire [1 ,2 ]
机构：
[1] Erasmus MC, Dept Cell Biol & Genet, Canc Genom Ctr, NL-3000 CA Rotterdam, Netherlands
[2] Erasmus MC, Dept Radiat Oncol, NL-3000 CA Rotterdam, Netherlands
来源：
CELL | 2008年 / 135卷 / 01期
关键词：
D O I：
10.1016/j.cell.2008.09.027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.
引用
收藏
页码：14 / 16
页数：3
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