Palladium-Catalyzed Cyclocarbonylation of 2-Halobenzaldehyde and Hydrazines: A Facile Synthesis of 2-Aminoisoindolin-1-ones

被引：5
作者：
Han, Chao [1 ]
Shen, Yang [1 ]
Lu, Ping [1 ]
Wang, Yanguang [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2013年 / 31卷 / 02期
基金：
中国国家自然科学基金;
关键词：
cyclocarbonylation; 2-aminoisoindolin-1-ones; multicomponent reactions; heterocycles; CARBONYLATIVE CYCLIZATION; DOMINO REACTION; MULTICOMPONENT REACTIONS; 2-IODOBENZOYL CHLORIDE; AMINES; 2-BROMOBENZALDEHYDE; STAUROSPORINE; ALDEHYDES; SEQUENCE; INDOLES;
D O I：
10.1002/cjoc.201200798
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient procedure for the synthesis of 2-aminoisoindolin-1-ones via a palladium-catalyzed three-component reaction of 2-halobenzaldehydes, hydrazines and carbon monoxide is reported. This cyclocarbonylation process can be performed smoothly under 1 atmospheric pressure of carbon monoxide to afford 2-aminoisoindolin-1-ones in moderate to excellent yields.
引用
收藏
页码：182 / 186
页数：5
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