Hydrogenation of Carboxylic Acids Catalyzed by Half-Sandwich Complexes of Iridium and Rhodium

被引：111

作者：

Brewster, Timothy P. ^{[1
]}

Miller, Alexander J. M. ^{[2
]}

Heinekey, D. Michael ^{[1
]}

Goldberg, Karen I. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[2] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 43期

基金：

美国国家科学基金会;

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; RUTHENIUM; DIHYDROGEN; ALCOHOLS; METHANOL; KETONES; RU(II); ESTERS; VALUES; WATER;

D O I：

10.1021/ja408149n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of half-sandwich Ir and Rh compounds are demonstrated to be competent catalysts for the hydrogenation of carboxylic acids under relatively mild conditions. Of the structurally diverse group of catalysts tested for activity, a Cp*Ir complex supported by an electron-releasing 2,2'-bipyridine ligand was the most active. Higher activity was achieved with employment of Bronsted or Lewis acid promoters. Mechanistic studies suggest a possible reaction pathway involving activated carboxylic acid substrates. The hydrogenation reaction was shown to be general to a variety of aliphatic acids.

引用

页码：16022 / 16025

页数：4

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