Chronic rhinosinusitis: an update on current pharmacotherapy

被引：5

作者：

Adriaensen, Gwijde F. J. P. M. ^{[1
]}

Fokkens, Wytske J. ^{[1
]}

机构：

[1] Acad Med Ctr, Dept Otorhinolaryngol, NL-1100 DD Amsterdam, Netherlands

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2013年 / 14卷 / 17期

关键词：

antibiotic; chronic rhinosinusitis; corticosteroid; mepolizumab; nasal irrigation; nasal polyps; omalizumab; reslizuma; ENDOSCOPIC SINUS SURGERY; PLACEBO-CONTROLLED TRIAL; RECALCITRANT CHRONIC RHINOSINUSITIS; NATIONAL COMPARATIVE AUDIT; DOUBLE-BLIND; LONG-TERM; NASAL POLYPS; STAPHYLOCOCCUS-AUREUS; ORAL STEROIDS; CORTICOSTEROID-THERAPY;

D O I：

10.1517/14656566.2013.837450

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal and paranasal mucosa with great impact on quality of life and a large financial burden on society. This article provides an overview of its current and future pharmacotherapy, the mainstay of CRS treatment. Areas covered: This article reviews the etiology, antibiotic and corticosteroid treatment, nasal irrigation therapy, bacterial lysates, anti-immunoglobulin E and anti-interleukin-5 therapy of CRS. This review highlights articles of interest on these topics in the PubMed database. Studies not in English language were excluded. Expert opinion: CRS is a spectrum of disease characterized by mucosal inflammation. Defining its various subtypes will change its medical treatment from general anti-inflammatory medicine towards tailor-made pharmacotherapy. The optimal timing of endoscopic sinus surgery in this treatment process remains to be defined.

引用

页码：2351 / 2360

页数：10

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