The many faces of β-TrCP E3 ubiquitin ligases:: reflections in the magic mirror of cancer

被引：276
作者：
Fuchs, SY
Spiegelman, VS
Kumar, KGS
机构：
[1] Univ Penn, Dept Anim Biol, Philadelphia, PA 19104 USA
[2] AMC, Canc Res Ctr, Lakewood, CO 80214 USA
来源：
ONCOGENE | 2004年 / 23卷 / 11期
关键词：
beta-TrCP; F-box; ubiquitin ligase; NF-kappa B; beta-catenin;
D O I：
10.1038/sj.onc.1207389
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFbeta-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying beta-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting beta-TrCP as a means of anticancer therapy are also discussed.
引用
收藏
页码：2028 / 2036
页数：9
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