MicroRNAs and cancer: past, present, and potential future

被引:238
|
作者
Nelson, Kristen M. [1 ]
Weiss, Glen J. [1 ,2 ]
机构
[1] Translat Genom Res Inst, Phoenix, AZ USA
[2] Scottsdale Clin Res Inst, Scottsdale, AZ USA
关键词
D O I
10.1158/1535-7163.MCT-08-0586
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MicroRNAs (miRNAs) are a class of small RNAs that have revealed a new level of gene regulation in the cell. After being processed by Drosha and Dicer RNase III endonucleases, mature miRNAs can inhibit the translation of mRNA by directing a RNA-induced silencing complex (RISC) to the target mRNA. miRNAs are making an impact in our understanding of cancer biology. Acting as either tumor suppressors or oncogenes, miRNAs regulate several genes known to play important roles in cancer. With the discovery of miRNAs comes the need for new techniques to study their activity. Bioinformatic tools can be used to predict mRNA targets of miRNA, but validation of miRNA regulation of predicted targets is imperative. miRNAs are differentially expressed in normal and tumor cells as well as between tumor subtypes. These differences may be useful as prognostic and predictive markers in cancer patients. The study of miRNAs holds much promise for improving diagnosis and treatment of cancer. [Mol Cancer Ther 2008;7(12):3655-60]
引用
收藏
页码:3655 / 3660
页数:6
相关论文
共 50 条
  • [1] Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future
    Alural, Begum
    Genc, Sermin
    Haggarty, Stephen J.
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2017, 73 : 87 - 103
  • [2] Hypersonics: Past, Present, and Potential Future
    Van Wie, David M.
    JOHNS HOPKINS APL TECHNICAL DIGEST, 2021, 35 (04): : 335 - 341
  • [3] Hypersonics: Past, Present, and Potential Future
    Van Wie, David M.
    Johns Hopkins APL Technical Digest (Applied Physics Laboratory), 2021, 35 (04): : 335 - 341
  • [4] Cancer immunotherapy: The past, the present and the future
    Parish, CR
    IMMUNOLOGY AND CELL BIOLOGY, 2003, 81 (02): : 106 - 113
  • [5] Cancer prevention: past, present, future
    Sugimura, T
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1998, 402 (1-2) : 7 - 14
  • [6] Anal Cancer: The Past, Present and Future
    Gondal, Talha Ashraf
    Chaudhary, Noman
    Bajwa, Husnaat
    Rauf, Aribah
    Le, Duc
    Ahmed, Shahid
    CURRENT ONCOLOGY, 2023, 30 (03) : 3232 - 3250
  • [7] CANCER CHEMOTHERAPY, PAST, PRESENT AND FUTURE
    BLOCH, A
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1977, 173 (MAR20): : 53 - 53
  • [8] Cancer prevention: Past, present, and future
    Young, RC
    Wilson, CM
    CLINICAL CANCER RESEARCH, 2002, 8 (01) : 11 - 16
  • [9] Cancer treatments: Past, present, and future
    Sonkin, Dmitriy
    Thomas, Anish
    Teicher, Beverly A.
    CANCER GENETICS, 2024, 286 : 18 - 24
  • [10] Mitochondria and Cancer: Past, Present, and Future
    Verschoor, M. L.
    Ungard, R.
    Harbottle, A.
    Jakupciak, J. P.
    Parr, R. L.
    Singh, G.
    BIOMED RESEARCH INTERNATIONAL, 2013, 2013