Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury

被引：46

作者：

Huang, Qian ^{[1
]}

Duan, Wanru ^{[1
,2
]}

Sivanesan, Eellan ^{[1
]}

Liu, Shuguang ^{[1
,3
]}

Yang, Fei ^{[4
]}

Chen, Zhiyong ^{[1
]}

Ford, Neil C. ^{[1
]}

Chen, Xueming ^{[5
]}

Guan, Yun ^{[1
,6
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA

[2] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China

[3] Xi An Jiao Tong Univ, Affiliated Hosp, Hong Hui Hosp, Dept Orthoped,Med Sch, Xian 710004, Shaanxi, Peoples R China

[4] Capital Med Univ, Dept Neurobiol, Beijing 100069, Peoples R China

[5] Capital Med Univ, Luhe Hosp, Dept Orthoped, Beijing 100020, Peoples R China

[6] Johns Hopkins Univ, Sch Med, Dept Neurol Surg, Baltimore, MD 21205 USA

来源：

NEUROSCIENCE BULLETIN | 2019年 / 35卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Pain; Trauma; Spinal cord injury; Spinal cord stimulation; Neuromodulation; Analgesia; CENTRAL NEUROPATHIC PAIN; DORSAL-HORN NEURONS; SODIUM-CHANNEL EXPRESSION; THALAMIC VPL NEURONS; ELECTRICAL-STIMULATION; KILOHERTZ-FREQUENCY; PHARMACOLOGICAL-TREATMENTS; INTRACTABLE PAIN; CHRONIC BACK; MECHANICAL HYPERSENSITIVITY;

D O I：

10.1007/s12264-018-0320-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI). Currently, however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation (SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations, classification, potential underlying etiology, and current challenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed.

引用

页码：527 / 539

页数：13