Ruthenium half-sandwich complexes bound to protein kinase Pim-1

被引：210
作者：
Debreczeni, JÉ
Bullock, AN
Atilla, GE
Williams, DS
Bregman, H
Knapp, S [1 ]
Meggers, E
机构：
[1] Univ Oxford, Ctr Struct Genom, Botnar Res Ctr, Oxford OX3 7LD, England
[2] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 10期
基金：
英国惠康基金;
关键词：
bioinorganic chemistry; inhibitors; proteins; ruthenium;
D O I：
10.1002/anie.200503468
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Keeping in shape with half a sandwich: The structure of a picomolar organoruthenium inhibitor bound to the ATP-binding site of the protein kinase Pim-1 (see picture) demonstrates that the ruthenium center has solely a structural role in organizing the organic ligands in the three-dimensional receptor space, thus yielding a structure that is complementary in shape and functional group presentation to the active site of Pim-1. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1580 / 1585
页数：6
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