Precision medicine in colorectal cancer: evolving genomic landscape and emerging consensus

被引：5

作者：

Fisher, Kurt W. ^{[1
]}

Lopez-Beltran, Antonio ^{[2
,3
]}

Montironi, Rodolfo ^{[4
]}

Cheng, Liang ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA

[2] Fac Med, Dept Surg, Unit Anat Pathol, E-14004 Cordoba, Spain

[3] Champalimaud Clin Ctr, P-1400038 Lisbon, Portugal

[4] Polytech Univ Marche Reg, Sch Med, Pathol Anat, Ancona, Italy

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 19期

关键词：

BRAF; colorectal cancer; KRAS; microsatellite instability; molecular diagnostics; NRAS; personalized medicine; CIRCULATING TUMOR-CELLS; COST-EFFECTIVENESS ANALYSIS; GROWTH-FACTOR RECEPTOR; BRAF MUTATION ANALYSIS; ISLAND METHYLATOR PHENOTYPE; CETUXIMAB PLUS IRINOTECAN; MISMATCH REPAIR STATUS; MULTICENTER PHASE-II; KRAS CODON 61; MICROSATELLITE INSTABILITY;

D O I：

10.2217/fon.15.219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer is the third most lethal cancer in men and women in the USA. Although surgical resection is the mainstay of treatment, many patients develop local and widely metastatic disease and become resistant to conventional chemotherapeutics. Recent comprehensive molecular characterization has led to subclassification of colorectal adenocarcinoma based on molecular properties, such as microsatellite instability and high CpG island methylation. These emerging subclassifications are associate with varying frequencies of RAS, BRAF, APC and other genetic events and have the ability to redefine therapeutic regimens. In this review, we examine how molecular diagnostics are currently used while providing insight into emerging implications for molecular analysis for personalized therapy in colorectal cancer.

引用

页码：2711 / 2719

页数：9

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