Development and validation of a m6A-related gene signature for predicting the prognosis of hepatocellular carcinoma

被引：5
|
作者：
Kong, Weihao [1 ]
Li, Xutong [2 ]
Xu, Honghai [3 ]
Gao, Yufeng [2 ]
机构：
[1] Anhui Med Univ, Dept Emergency Surg, Dept Emergency Med, Affiliated Hosp 1, Hefei 230022, Peoples R China
[2] Anhui Med Univ, Dept Infect Dis, Affiliated Hosp 1, Hefei 230022, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Dept Pathol, Hefei 230022, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 13期
关键词：
liver cancer; m(6)A RNA methylation; prognosis; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER;
D O I：
10.2217/bmm-2020-0178
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background:This study aimed to investigate the prognostic role of m(6)A methylation regulators in hepatocellular carcinoma (HCC).Materials & methods:Gene expression matrices were downloaded from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium, and Gene Expression Omnibus databases. Univariate and multivariate regression analysis were utilized to determine the m(6)A risk genes.Results:Two m(6)A-related risk genes (YTHDF1, YTHDF2) were identified in the TCGA HCC cohort. The m(6)A-correlated risk score is an independent risk factor for the overall survival of the TCGA HCC cohort. Finally, we verified the reliability of our results using three external datasets.Conclusion:The m(6)A-correlated gene signature has prognostic value in HCC patients and thus provides guidance for the treatment of HCC.
引用
收藏
页码：1217 / 1228
页数：12
相关论文
共 50 条
  • [41] 8DEstablishment and validation of a hypoxia-related signature predicting prognosis in hepatocellular carcinoma
    Cai, Congbo
    Yang, Lei
    Zhou, Kena
    BMC GASTROENTEROLOGY, 2021, 21 (01)
  • [42] 8DEstablishment and validation of a hypoxia-related signature predicting prognosis in hepatocellular carcinoma
    Congbo Cai
    Lei Yang
    Kena Zhou
    BMC Gastroenterology, 21
  • [43] The m6A-Related mRNA Signature Predicts the Prognosis of Pancreatic Cancer Patients
    Meng, Zibo
    Yuan, Qingchen
    Zhao, Jingyuan
    Wang, Bo
    Li, Shoukang
    Offringa, Rienk
    Jin, Xin
    Wu, Heshui
    MOLECULAR THERAPY-ONCOLYTICS, 2020, 17 : 460 - 470
  • [44] Identification and Validation of a Novel Six-Gene Expression Signature for Predicting Hepatocellular Carcinoma Prognosis
    Yan, Zongcai
    He, Meiling
    He, Lifeng
    Wei, Liuxia
    Zhang, Yumei
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [45] Identification of m6A-related lncRNAs-based signature for predicting the prognosis of patients with skin cutaneous melanoma
    Lin, Wentao
    Tan, Zhou-yong
    Fang, Xi-chi
    SLAS TECHNOLOGY, 2024, 29 (01): : 100101
  • [46] A Novel m6A-Related LncRNA Signature for Predicting Prognosis, Chemotherapy and Immunotherapy Response in Patients with Lung Adenocarcinoma
    Shen, Yefeng
    Wang, Shaochun
    Wu, Yuanzhou
    CELLS, 2022, 11 (15)
  • [47] MrGPS: an m6A-related gene pair signature to predict the prognosis and immunological impact of glioma patients
    Zhang, Ning
    Yang, Fengxia
    Zhao, Pengfei
    Jin, Nana
    Wu, Haonan
    Liu, Tao
    Geng, Qingshan
    Yang, Xiaojun
    Cheng, Lixin
    BRIEFINGS IN BIOINFORMATICS, 2024, 25 (01)
  • [48] Development and Validation of a Ferroptosis-Related Gene Signature and Nomogram for Predicting the Prognosis of Esophageal Squamous Cell Carcinoma
    Ye, Jiecheng
    Wu, Yining
    Cai, Heyuan
    Sun, Li
    Deng, Wanying
    Liang, Ruikun
    Han, Anjia
    FRONTIERS IN GENETICS, 2021, 12
  • [49] Development and validation of a copper-related gene prognostic signature in hepatocellular carcinoma
    Shi, Haoting
    Huang, Jingxuan
    Wang, Xue
    Li, Runchuan
    Shen, Yiqing
    Jiang, Bowen
    Ran, Jinjun
    Cai, Rong
    Guo, Fang
    Wang, Yufei
    Ren, Gang
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
  • [50] Identification of an m6A-Related Signature as Biomarker for Hepatocellular Carcinoma Prognosis and Correlates with Sorafenib and Anti-PD-1 Immunotherapy Treatment Response
    Jiang, Hongye
    Ning, Gang
    Wang, Yensheng
    Lv, Weibiao
    DISEASE MARKERS, 2021, 2021
12345