Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice

被引:25
|
作者
Yu, Shu Yan [1 ,2 ]
Gao, Rui [3 ]
Zhang, Lin [1 ]
Luo, Junxia [1 ]
Jiang, Hong [4 ]
Wang, Shuanglian [1 ,2 ]
机构
[1] Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Sch Med, Key Lab Med Neurol, Jinan 250012, Shandong, Peoples R China
[3] Jinan Nursing Vocat Coll, Dept Microorganism, Jinan 250012, Shandong, Peoples R China
[4] Shandong Univ, Sch Med, Inst Psychol, Jinan 250012, Shandong, Peoples R China
来源
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2013年 / 44卷
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
Curcumin; Ethanol; Memory deficit; Nitric oxide; Nitric oxide synthase; OBJECT RECOGNITION MEMORY; ENDOTHELIAL DYSFUNCTION; BEHAVIORAL DEFICITS; CEREBRAL-ISCHEMIA; IN-VIVO; RATS; ALCOHOL; CONSOLIDATION; AMYGDALA; MODEL;
D O I
10.1016/j.pnpbp.2013.03.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Ethanol consumption has well-known deleterious effects on memory. However, the mechanism by which ethanol exerts its effects on memory has received little attention, which has retarded the identification and development of effective therapeutic strategies against ethanol toxicity. The aim of this study was to explore the neuronal mechanisms underlying the protective action of curcumin, a natural polyphenolic compound of Curcuma longa, against ethanol-induced memory deficits. Adult mice were pretreated with curcumin (40 mg/kg, i.p.) before administration of ethanol (1 g/kg, i.p.) for the memory acquisition measurement, or were sacrificed 30 mm later for evaluation of regional brain differences in the nitric oxide synthase (NOS) activity and nitric oxide (NO) concentration. The results showed that pretreatment with curcumin significantly ameliorated the memory deficits resulting from acute ethanol administration to mice in the novel object recognition and inhibitory avoidance tasks. Furthermore, acute ethanol treatment increased the NOS activity and NO production in brain regions associated with memory including prefrontal cortex (PFC), amygdala and hippocampus, while this enhancement was suppressed by pretreatment with curcumin. Taken together, these results suggest that the protective effects of curcumin on acute ethanol-induced memory deficits are mediated, at least in part, by suppressing NOS activity in the brain of mice. Thus, manipulation of the NOS/NO signaling pathway might be beneficial for the prevention of ethanol toxicity. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:210 / 216
页数:7
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