Shades of gray between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications

被引:39
作者
Harris, Nancy L. [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
classification; immunophenotype; lymphoma; CD23; EXPRESSION; LIMITED-STAGE; ZONE LYMPHOMA; MARKER; DISTINGUISHES; SIGNATURE; CHILDREN; FEATURES; TUMOR;
D O I
10.1038/modpathol.2012.182
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Hodgkin lymphomas (HLs) are neoplasms of large B cells. Two types are recognized: nodular lymphocyte predominant HL (NLPHL) and classical HL (CHL). In both types, there may be morphological and possibly biological overlap with large B-cell lymphomas (LBCLs) of non-HL types. These include nodular sclerosis CHL and primary mediastinal large B-cell lymphoma; CHL rich in lymphocytes and NLPHL; and NLPHL and T-cell/histiocyte-rich LBCL. This review covers the defining features of each of these diseases, the borderlines between them, and strategies for differential diagnosis. Modern Pathology (2013) 26, S57-S70; doi:10.1038/modpathol.2012.182
引用
收藏
页码:S57 / S70
页数:14
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