Empirical measurements of biomechanical anisotropy of the human vocal fold lamina propria

被引:24
作者
Kelleher, Jordan E. [1 ]
Siegmund, Thomas [1 ]
Du, Mindy [2 ]
Naseri, Elhum [2 ]
Chan, Roger W. [2 ]
机构
[1] Purdue Univ, W Lafayette, IN 47907 USA
[2] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
Indentation; Tensile deformation; Anisotropy; Larynx; Biomechanics; BIDIRECTIONAL MECHANICAL-PROPERTIES; FUNDAMENTAL-FREQUENCY REGULATION; HALF-SPACES; GLENOHUMERAL CAPSULE; HERTZIAN CONTACT; STRESS-STRAIN; CORTICAL BONE; IN-VIVO; INDENTATION; TISSUES;
D O I
10.1007/s10237-012-0425-4
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The vocal folds are known to be mechanically anisotropic due to the microstructural arrangement of fibrous proteins such as collagen and elastin in the lamina propria. Even though this has been known for many years, the biomechanical anisotropic properties have rarely been experimentally studied. We propose that an indentation procedure can be used with uniaxial tension in order to obtain an estimate of the biomechanical anisotropy within a single specimen. Experiments were performed on the lamina propria of three male and three female human vocal folds dissected from excised larynges. Two experiments were conducted: each specimen was subjected to cyclic uniaxial tensile loading in the longitudinal (i.e., anterior-posterior) direction, and then to cyclic indentation loading in the transverse (i.e., medial-lateral) direction. The indentation experiment was modeled as contact on a transversely isotropic half-space using the Barnett-Lothe tensors. The longitudinal elastic modulus E (L) was computed from the tensile test, and the transverse elastic modulus E (T) and longitudinal shear modulus G (L) were obtained by inverse analysis of the indentation force-displacement response. It was discovered that the average of E (L) /E (T) was 14 for the vocal ligament and 39 for the vocal fold cover specimens. Also, the average of E (L) /G (L) , a parameter important for models of phonation, was 28 for the vocal ligament and 54 for the vocal fold cover specimens. These measurements of anisotropy could contribute to more accurate models of fundamental frequency regulation and provide potentially better insights into the mechanics of vocal fold vibration.
引用
收藏
页码:555 / 567
页数:13
相关论文
共 55 条
[1]   A finite-element model of vocal-fold vibration [J].
Alipour, F ;
Berry, DA ;
Titze, IR .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 2000, 108 (06) :3003-3012
[2]  
BARNETT DM, 1975, PHYS NORV, V8, P13
[3]   Normal modes in a continuum model of vocal fold tissues [J].
Berry, DA ;
Titze, IR .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1996, 100 (05) :3345-3354
[4]  
Bühler RB, 2011, ARCH OTOLARYNGOL, V137, P604, DOI 10.1001/archoto.2011.88
[5]   Gender-related differences of hyaluronic acid distribution in the human vocal fold [J].
Butler, JE ;
Hammond, TH ;
Gray, SD .
LARYNGOSCOPE, 2001, 111 (05) :907-911
[6]   A simple-shear rheometer for linear viscoelastic characterization of vocal fold tissues at phonatory frequencies [J].
Chan, Roger W. ;
Rodriguez, Maritza L. .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 2008, 124 (02) :1207-1219
[7]   Relative contributions of collagen and elastin to elasticity of the vocal fold under tension [J].
Chan, Roger W. ;
Fu, Min ;
Young, Lindsay ;
Tirunagari, Neeraj .
ANNALS OF BIOMEDICAL ENGINEERING, 2007, 35 (08) :1471-1483
[8]   Biomechanics of fundamental frequency regulation: Constitutive modeling of the vocal fold lamina propria [J].
Chan, Roger W. ;
Siegmund, Thomas ;
Zhang, Kai .
LOGOPEDICS PHONIATRICS VOCOLOGY, 2009, 34 (04) :181-189
[9]   Effect of postmortem changes and freezing on the viscoelastic properties of vocal fold tissues [J].
Chan, RW ;
Titze, IR .
ANNALS OF BIOMEDICAL ENGINEERING, 2003, 31 (04) :482-491
[10]   Measurement of Young's Modulus of Vocal Folds by Indentation [J].
Chhetri, Dinesh K. ;
Zhang, Zhaoyan ;
Neubauer, Juergen .
JOURNAL OF VOICE, 2011, 25 (01) :1-7