Role of Reduced β-Cell Mass Versus Impaired β-Cell Function in the Pathogenesis of Type 2 Diabetes

被引：186
作者：
Meier, Juris J. [1 ]
Bonadonna, Riccardo C. [2 ,3 ]
机构：
[1] Ruhr Univ Bochum, St Josef Hosp, Div Diabetol & Gastrointestinal Endocrinol, Bochum, Germany
[2] Univ Verona, Dept Med, I-37100 Verona, Italy
[3] Azienda Osped Univ Integrata Verona, Div Endocrinol & Metab Dis, Verona, Italy
来源：
DIABETES CARE | 2013年 / 36卷
关键词：
PULSATILE INSULIN-SECRETION; LOW-BIRTH-WEIGHT; GLUCOSE-TOLERANCE; PARTIAL PANCREATECTOMY; INTRAVENOUS GLUCOSE; GLUCAGON-SECRETION; PLASMA-GLUCOSE; MELLITUS; HEMIPANCREATECTOMY; ASSOCIATION;
D O I：
10.2337/dcS13-2008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：S113 / S119
页数：7
相关论文
共 75 条
[61]   BETA-CELLS IN TYPE-II DIABETES-MELLITUS [J].
PORTE, D .
DIABETES, 1991, 40 (02) :166-180
[62]   Combined pancreas and kidney transplantation in a lean type 2 diabetic patient.: Effects on insulin secretion and sensitivity [J].
Pox, C ;
Ritzel, R ;
Büsing, M ;
Meier, JJ ;
Klempnauer, J ;
Schmiegel, W ;
Nauck, MA .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2002, 110 (08) :420-424
[63]   Pancreatic β-cell mass in European subjects with type 2 diabetes [J].
Rahier, J. ;
Guiot, Y. ;
Goebbels, R. M. ;
Sempoux, C. ;
Henquin, J. C. .
DIABETES OBESITY & METABOLISM, 2008, 10 :32-42
[64]   Adaptive β-cell Proliferation Is Severely Restricted With Advanced Age [J].
Rankin, Matthew M. ;
Kushner, Jake A. .
DIABETES, 2009, 58 (06) :1365-1372
[65]   Diabetes, glucose toxicity, and oxidative stress:: A case of double jeopardy for the pancreatic islet β cell [J].
Robertson, R. Paul ;
Harmon, Jamie S. .
FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (02) :177-184
[66]  
Robertson RP, 2002, TRANSPLANTATION, V73, P736
[67]   Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes [J].
Rosengren, Anders H. ;
Braun, Matthias ;
Mandi, Taman ;
Andersson, Sofia A. ;
Travers, Mary E. ;
Shigeto, Makoto ;
Zhang, Enming ;
Almgren, Peter ;
Ladenvall, Claes ;
Axelsson, Annika S. ;
Edlund, Anna ;
Pedersen, Morten Gram ;
Jonsson, Anna ;
Ramracheya, Reshma ;
Tang, Yunzhao ;
Walker, Jonathan N. ;
Barrett, Amy ;
Johnson, Paul R. V. ;
Lyssenko, Valeriya ;
McCarthy, Mark I. ;
Groop, Leif ;
Salehi, Albert ;
Gloyn, Anna L. ;
Renstrom, Erik ;
Rorsman, Patrik ;
Eliasson, Lena .
DIABETES, 2012, 61 (07) :1726-1733
[68]   Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans [J].
Seaquist, ER ;
Kahn, SE ;
Clark, PM ;
Hales, CN ;
Porte, D ;
Robertson, RP .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (02) :455-460
[69]   Effect of acute hyperglycemia on insulin secretion in humans [J].
Toschi, E ;
Camastra, S ;
Sironi, AM ;
Masoni, A ;
Gastaldelli, A ;
Mari, A ;
Ferrannini, E ;
Natali, A .
DIABETES, 2002, 51 :S130-S133
[70]   CACNA1E Variants Affect Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 3 [J].
Trombetta, Maddalena ;
Bonetti, Sara ;
Boselli, MariaLinda ;
Turrini, Fabiola ;
Malerba, Giovanni ;
Trabetti, Elisabetta ;
Pignatti, PierFranco ;
Bonora, Enzo ;
Bonadonna, Riccardo C. .
PLOS ONE, 2012, 7 (03)
12345678