Microfluidic techniques for tumor cell detection

被引：8

作者：

Tan, Feifei ^{[1
]}

Wang, Tianbao ^{[1
]}

Wang, Haishi ^{[1
]}

Zheng, Yuzheng ^{[1
]}

机构：

[1] Chengdu Univ Informat Technol, Coll Commun Engn, 24 Block 1,Xuefu Rd, Chengdu 610225, Sichuan, Peoples R China

来源：

ELECTROPHORESIS | 2019年 / 40卷 / 08期

关键词：

Biosensor; Microfluidics; Single cell analysis; Tumor cells; CANCER-PATIENTS; DIELECTROPHORESIS; SEPARATION; CAPILLARY; CHIP; PARTICLE; DEVICE; BLOOD; ARRAY; FLOW;

D O I：

10.1002/elps.201800413

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer metastasis is the main cause of cancer-related death. Early detection of tumor cell in peripheral blood is of great significant to early diagnosis and effective treatment of cancer. Over the past two decades, microfluidic technologies have been demonstrated to have great potential for isolating and detecting tumor cell from blood. The present paper reviews microfluidic techniques for tumor cell detection based on various physical principles. The specific methods are categorized into active and passive methods depending on whether extra force field is applied. Working principles of the two methods are explained in detail, including microfluidics combined with optical tweezer, electric field, magnetic field, acoustophoresis, and without extra fields for tumor cell detection. Typical experiments and the results are reviewed. Based on these, research characteristics of the two methods are analyzed.

引用

页码：1230 / 1244

页数：15

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