The promiscuity of ARF interactions with the proteasome

被引：24

作者：

Pollice, Alessandra ^{[1
]}

Vivo, Maria ^{[1
]}

La Mantia, Girolama ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Struct & Funct Biol, Naples, Italy

来源：

FEBS LETTERS | 2008年 / 582卷 / 23-24期

关键词：

p14/p19ARF; Proteasome; Cell stress sensor; REG-gamma; TBP-1/PSMC3;

D O I：

10.1016/j.febslet.2008.09.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor suppressor ARF is one of the most important oncogenic stress sensors in mammalian cells. Its effect is exerted through the interaction with different cellular partners, often resulting in their functional inactivation. This review focuses on the role played by the proteasome in ARF regulation of protein turnover and the function of most of its interacting partners. Specific proteasome components appear to be involved in the regulation of ARF turnover, bringing to light a complex network of interactions between ARF and the proteasome. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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收藏

页码：3257 / 3262

页数：6

相关论文

共 69 条

[61] The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2 [J].

Stott, FJ ;

Bates, S ;

James, MC ;

McConnell, BB ;

Starborg, M ;

Brookes, S ;

Palmero, I ;

Ryan, K ;

Hara, E ;

Vousden, KH ;

Peters, G .

EMBO JOURNAL, 1998, 17 (17) :5001-5014

[62] Sumoylation induced by the Arf tumor suppressor: A p53-independent function [J].

Tago, K ;

Chiocca, S ;

Sherr, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (21) :7689-7694

[63] Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence [J].

Takaoka, A ;

Hayakawa, S ;

Yanai, H ;

Stoiber, D ;

Negishi, H ;

Kikuchi, H ;

Sasaki, S ;

Imai, K ;

Shibue, T ;

Honda, K ;

Taniguchi, T .

NATURE, 2003, 424 (6948) :516-523

[64] p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase [J].

Woods, YL ;

Xirodimas, DP ;

Prescott, AR ;

Sparks, A ;

Lane, DP ;

Saville, MK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (48) :50157-50166

[65] P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2 [J].

Xirodimas, DP ;

Chisholm, J ;

Desterro, JMS ;

Lane, DP ;

Hay, RT .

FEBS LETTERS, 2002, 528 (1-3) :207-211

[66] REGγ proteasome activator is involved in the maintenance of chromosomal stability [J].

Zannini, Laura ;

Lecis, Daniele ;

Buscemi, Giacomo ;

Carlessi, Luigi ;

Gasparini, Patrizia ;

Fontanella, Enrico ;

Lisanti, Sofia ;

Barton, Lance ;

Delia, Domenico .

CELL CYCLE, 2008, 7 (04) :504-512

[67] Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP [J].

Zhang, OH ;

Yoshimatsu, Y ;

Hildebrand, J ;

Frisch, SM ;

Goodman, RH .

CELL, 2003, 115 (02) :177-186

[68] ARF promotes MDM2 degradation and stabilizes p53:: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways [J].

Zhang, YP ;

Xiong, Y ;

Yarbrough, WG .

CELL, 1998, 92 (06) :725-734

[69] REGγ:: A shortcut to destruction [J].

Zhou, PB .

CELL, 2006, 124 (02) :256-257

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