The promiscuity of ARF interactions with the proteasome

被引：24

作者：

Pollice, Alessandra ^{[1
]}

Vivo, Maria ^{[1
]}

La Mantia, Girolama ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Struct & Funct Biol, Naples, Italy

来源：

FEBS LETTERS | 2008年 / 582卷 / 23-24期

关键词：

p14/p19ARF; Proteasome; Cell stress sensor; REG-gamma; TBP-1/PSMC3;

D O I：

10.1016/j.febslet.2008.09.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor suppressor ARF is one of the most important oncogenic stress sensors in mammalian cells. Its effect is exerted through the interaction with different cellular partners, often resulting in their functional inactivation. This review focuses on the role played by the proteasome in ARF regulation of protein turnover and the function of most of its interacting partners. Specific proteasome components appear to be involved in the regulation of ARF turnover, bringing to light a complex network of interactions between ARF and the proteasome. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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收藏

页码：3257 / 3262

页数：6

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