Aligned bacterial PHBV nanofibrous conduit for peripheral nerve regeneration

被引:8
|
作者
Demirbilek, Murat [1 ]
Sakar, Mustafa [2 ]
Karahaliloglu, Zeynep [3 ,4 ]
Erdal, Ebru [3 ,4 ]
Yalcin, Eda [3 ]
Bozkurt, Gokhan [2 ]
Korkusuz, Petek [5 ]
Bilgic, Elif [5 ]
Temucin, Cagri Mesut [6 ]
Denkbas, Emir Baki [7 ]
机构
[1] Bayindir Hosp, Ankara, Turkey
[2] Hacettepe Univ, Fac Med, Dept Neurosurg, TR-06800 Ankara, Turkey
[3] Hacettepe Univ, Dept Chem, Div Nanotechnol & Nanomed, TR-06800 Ankara, Turkey
[4] Aksaray Univ, Dept Biol, Aksaray, Turkey
[5] Hacettepe Univ, Fac Med, Dept Histol & Embryol, TR-06800 Ankara, Turkey
[6] Hacettepe Univ, Fac Med, Dept Neurol, TR-06800 Ankara, Turkey
[7] Hacettepe Univ, Dept Chem, Div Biochem, TR-06800 Ankara, Turkey
关键词
aligned scaffold; bacterial PHBV; peripheral nerve regeneration; regenerative medicine; GLIAL GROWTH; GAP REPAIR; SCAFFOLDS; HYDROXYBUTYRATE; COLLAGEN; ACID; TUBE;
D O I
10.3109/21691401.2013.875033
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The conventional method of peripheral nerve gap treatment is autografting. This method is limited. In this study, an aligned nanofibrous graft was formed using microbial polyester, Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The regenerative effect of the graft was compared with that of autografting in vivo. To determine the regenerative effect, rats were assessed with sciatic nerve functional index, electromyographic evaluation, and histological evaluation. Results found in this study include PHBV grafts stimulated progressive nerve regeneration, although regeneration was not comparable with that of autografting. We conclude that the study results were promising for aligned bacterial polymeric grafts for peripheral nerve regeneration.
引用
收藏
页码:243 / 251
页数:9
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