Copper-Catalyzed Aerobic Oxidative C-H and C-C Functionalization of 1-[2-(Arylamino)aryl]ethanones Leading to Acridone Derivatives

被引：52
|
作者：
Yu, Jipan [1 ]
Yang, Haijun [1 ]
Jiang, Yuyang [2 ]
Fu, Hua [1 ,2 ]
机构：
[1] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Dept Chem, Minist Educ, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol Guangdong Prov, Shenzhen 518057, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 13期
基金：
中国国家自然科学基金;
关键词：
C-C activation; C-H activation; cyclization; nitrogen heterocycles; synthetic methods; CROSS-COUPLING REACTIONS; ARYL BOND FORMATION; ONE-POT SYNTHESIS; N-ARYLATION; AMINO-ACIDS; PALLADIUM; ACTIVATION; AMINATION; ULLMANN; NITROGEN;
D O I：
10.1002/chem.201204169
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Efficient copper-catalyzed aerobic oxidative C-H and C-C functionalization of 1-[2-(arylamino)aryl]ethanones leading to acridones has been developed. The procedure involves cleavage of aromatic C-H and acetyl C-C bonds with intramolecular formation of a diarylketone bond. The protocol uses inexpensive Cu(O2CCF3)(2) as catalyst, pyridine as additive, and economical and environmentally friendly oxygen as the oxidant, and the corresponding acridones with various functional groups were obtained in moderate to good yields.
引用
收藏
页码：4271 / 4277
页数：7
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