T cells in Systemic Lupus Erythematosus

被引：160
作者：
Suarez-Fueyo, Abel [1 ]
Bradley, Sean J. [1 ]
Tsokos, George C. [1 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2016年 / 43卷
关键词：
PROTEIN-KINASE IV; FOLLICULAR HELPER; MECHANISTIC TARGET; ACTIVATION; DISEASE; DIFFERENTIATION; CONTRIBUTES; PATHOGENESIS; GENERATION; EXPRESSION;
D O I：
10.1016/j.coi.2016.09.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Systemic Lupus Erythematosus is an autoimmune disorder caused by a complex combination of genetic, epigenetic and environmental factors. Different polymorphisms and epigenetic modifications lead to altered gene expression and function of several molecules which lead to abnormal T cell responses. Metabolic and functional alterations result in peripheral tolerance failures and biased differentiation of T cells into pro inflammatory and B cell-helper phenotypes as well as the accumulation of disease-promoting memory T cells. Understanding these T cell alterations and their origins is necessary to develop more accurate patient classification systems and to discover new therapeutic targets.
引用
收藏
页码：32 / 38
页数：7
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