Self-Exploding Beads Releasing Microcarriers

被引：58
作者：
De Geest, Bruno G. [1 ,2 ]
De Koker, Stefaan [1 ]
Immesoete, Kristof [1 ]
Demeester, Jo [1 ]
De Smedt, Stefaan C. [1 ]
Hennink, Wim E. [2 ]
机构：
[1] Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium
[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CA Utrecht, Netherlands
来源：
ADVANCED MATERIALS | 2008年 / 20卷 / 19期
关键词：
D O I：
10.1002/adma.200800907
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Self-exploding polyelectrolyte-coated gel beads releasing micrometer-sized capsules at the time of explosion consist of degradable hydrogel beads loaded with 3 mu m sized layer-by-layer (LbL) microcapsules. When the polyelectrolyte coated gel beads explode, the smaller LbL microcapsules are suddenly released.
引用
收藏
页码：3687 / +
页数：6
相关论文
共 36 条
[1]   Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating [J].
Caruso, F ;
Caruso, RA ;
Möhwald, H .
SCIENCE, 1998, 282 (5391) :1111-1114
[2]   Layer-by-layer coating of degradable microgels for pulsed drug delivery [J].
De Geest, B. G. ;
Dejugnat, C. ;
Verhoeven, E. ;
Sukhorukov, G. B. ;
Jonas, A. M. ;
Plain, J. ;
Demeester, J. ;
De Smedt, S. C. .
JOURNAL OF CONTROLLED RELEASE, 2006, 116 (02) :159-169
[3]   Self-exploding lipid-coated microgels [J].
De Geest, BG ;
Stubbe, BG ;
Jonas, AM ;
Van Thienen, T ;
Hinrichs, WLJ ;
Demeester, J ;
De Smedt, SC .
BIOMACROMOLECULES, 2006, 7 (01) :373-379
[4]   Self-rupturing microcapsules [J].
De Geest, BG ;
Déjugnat, C ;
Sukhorukov, GB ;
Braeckmans, K ;
De Smedt, SC ;
Demeester, J .
ADVANCED MATERIALS, 2005, 17 (19) :2357-+
[5]   Intracellularly degradable polyelectrolyte microcapsules [J].
De Geest, BG ;
Vandenbroucke, RE ;
Guenther, AM ;
Sukhorukov, GB ;
Hennink, WE ;
Sanders, NN ;
Demeester, J ;
De Smedt, SC .
ADVANCED MATERIALS, 2006, 18 (08) :1005-+
[6]   Biodegradable microcapsules designed via 'click' chemistry [J].
De Geest, Bruno G. ;
Van Camp, Wim ;
Du Prez, Filip E. ;
De Smedt, Stefaan C. ;
Demeester, Jo ;
Hennink, Wim E. .
CHEMICAL COMMUNICATIONS, 2008, (02) :190-192
[7]   Self-rupturing and hollow microcapsules prepared from bio-polyelectrolyte-coated microgels [J].
De Geest, Bruno G. ;
Dejugnat, Christophe ;
Prevot, Michelle ;
Sukhorukov, Gleb B. ;
Demeester, Joseph ;
De Smedt, Stefaan C. .
ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (04) :531-537
[8]   In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules [J].
De Koker, Stefaan ;
De Geest, Bruno G. ;
Cuvelier, Claude ;
Ferdinande, Liesbeth ;
Deckers, Wies ;
Hennink, Wim E. ;
De Smedt, Stefaan ;
Mertens, Nico .
ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (18) :3754-3763
[9]   Fuzzy nanoassemblies: Toward layered polymeric multicomposites [J].
Decher, G .
SCIENCE, 1997, 277 (5330) :1232-1237
[10]  
Donath E, 1998, ANGEW CHEM INT EDIT, V37, P2202, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2201::AID-ANIE2201>3.0.CO
1234