Self-Exploding Beads Releasing Microcarriers

被引：58
作者：
De Geest, Bruno G. [1 ,2 ]
De Koker, Stefaan [1 ]
Immesoete, Kristof [1 ]
Demeester, Jo [1 ]
De Smedt, Stefaan C. [1 ]
Hennink, Wim E. [2 ]
机构：
[1] Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium
[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CA Utrecht, Netherlands
来源：
ADVANCED MATERIALS | 2008年 / 20卷 / 19期
关键词：
D O I：
10.1002/adma.200800907
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Self-exploding polyelectrolyte-coated gel beads releasing micrometer-sized capsules at the time of explosion consist of degradable hydrogel beads loaded with 3 mu m sized layer-by-layer (LbL) microcapsules. When the polyelectrolyte coated gel beads explode, the smaller LbL microcapsules are suddenly released.
引用
收藏
页码：3687 / +
页数：6
相关论文
共 36 条
  • [1] Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating
    Caruso, F
    Caruso, RA
    Möhwald, H
    [J]. SCIENCE, 1998, 282 (5391) : 1111 - 1114
  • [2] Layer-by-layer coating of degradable microgels for pulsed drug delivery
    De Geest, B. G.
    Dejugnat, C.
    Verhoeven, E.
    Sukhorukov, G. B.
    Jonas, A. M.
    Plain, J.
    Demeester, J.
    De Smedt, S. C.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2006, 116 (02) : 159 - 169
  • [3] Self-exploding lipid-coated microgels
    De Geest, BG
    Stubbe, BG
    Jonas, AM
    Van Thienen, T
    Hinrichs, WLJ
    Demeester, J
    De Smedt, SC
    [J]. BIOMACROMOLECULES, 2006, 7 (01) : 373 - 379
  • [4] Self-rupturing microcapsules
    De Geest, BG
    Déjugnat, C
    Sukhorukov, GB
    Braeckmans, K
    De Smedt, SC
    Demeester, J
    [J]. ADVANCED MATERIALS, 2005, 17 (19) : 2357 - +
  • [5] Intracellularly degradable polyelectrolyte microcapsules
    De Geest, BG
    Vandenbroucke, RE
    Guenther, AM
    Sukhorukov, GB
    Hennink, WE
    Sanders, NN
    Demeester, J
    De Smedt, SC
    [J]. ADVANCED MATERIALS, 2006, 18 (08) : 1005 - +
  • [6] Biodegradable microcapsules designed via 'click' chemistry
    De Geest, Bruno G.
    Van Camp, Wim
    Du Prez, Filip E.
    De Smedt, Stefaan C.
    Demeester, Jo
    Hennink, Wim E.
    [J]. CHEMICAL COMMUNICATIONS, 2008, (02) : 190 - 192
  • [7] Self-rupturing and hollow microcapsules prepared from bio-polyelectrolyte-coated microgels
    De Geest, Bruno G.
    Dejugnat, Christophe
    Prevot, Michelle
    Sukhorukov, Gleb B.
    Demeester, Joseph
    De Smedt, Stefaan C.
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (04) : 531 - 537
  • [8] In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules
    De Koker, Stefaan
    De Geest, Bruno G.
    Cuvelier, Claude
    Ferdinande, Liesbeth
    Deckers, Wies
    Hennink, Wim E.
    De Smedt, Stefaan
    Mertens, Nico
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (18) : 3754 - 3763
  • [9] Fuzzy nanoassemblies: Toward layered polymeric multicomposites
    Decher, G
    [J]. SCIENCE, 1997, 277 (5330) : 1232 - 1237
  • [10] Donath E, 1998, ANGEW CHEM INT EDIT, V37, P2202, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2201::AID-ANIE2201>3.0.CO
1234