Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network

被引：97

作者：

Ludwig, Heinz ^{[1
]}

Boccadoro, Mario ^{[2
]}

Moreau, Philippe ^{[3
]}

San-Miguel, Jesus ^{[4
]}

Cavo, Michele ^{[5
]}

Pawlyn, Charlotte ^{[6
]}

Zweegman, Sonja ^{[7
]}

Facon, Thierry ^{[8
]}

Driessen, Christoph ^{[9
]}

Hajek, Roman ^{[10
,11
]}

Dimopoulos, Melitios A. ^{[12
]}

Gay, Francesca ^{[2
]}

Avet-Loiseau, Herve ^{[13
]}

Terpos, Evangelos ^{[12
]}

Zojer, Niklas ^{[14
]}

Mohty, Mohamad ^{[15
]}

Mateos, Maria-Victoria ^{[16
]}

Einsele, Hermann ^{[17
]}

Delforge, Michel ^{[18
]}

Caers, Jo ^{[19
]}

Weisel, Katja ^{[20
]}

Jackson, Graham ^{[21
]}

Garderet, Laurent ^{[22
]}

Engelhardt, Monika ^{[23
]}

van de Donk, Niels ^{[7
]}

Leleu, Xavier ^{[24
]}

Goldschmidt, Hartmut ^{[25
,26
]}

Beksac, Meral ^{[27
]}

Nijhof, Inger ^{[7
]}

Abildgaard, Niels ^{[28
]}

Bringhen, Sara ^{[2
]}

Sonneveld, Pieter ^{[29
]}

机构：

[1] Ctr Oncol Hematol & Palliat Care, Wilhelminen Canc Res Inst, Dept Med 1, Clin Ottakring, Vienna, Austria

[2] Azienda Osped Univ Citta Salute & Sci, Div Hematol, Myeloma Unit, Turin, Italy

[3] CHU Poitiers, Serv Hematol & Therapie Cellulaire, PRC Cic Inserm 1402, Poitiers, France

[4] Clin Univ Navarra, CIBERONC, IDISNA, CIMA, Pamplona, Spain

[5] Bologna Univ, Seragnoli Inst Hematol, Sch Med, Bologna, Italy

[6] Inst Canc Res, London, England

[7] Vrije Univ Amsterdam, Dept Hematol, Amsterdam UMC, Amsterdam, Netherlands

[8] Lille Univ Hosp, Hop Claude Huriez, Lille, France

[9] Cantonal Hosp St Gallen, Dept Med Oncol & Hematol, St Gallen, Switzerland

[10] Univ Ostrava, Dept Hematooncol, Univ Hosp Ostrava, Ostrava, Czech Republic

[11] Univ Ostrava, Fac Med, Ostrava, Czech Republic

[12] Natl & Kapodistrian Univ Athens, Dept Clin Therapeut, Hematol & Med Oncol, Athens, Greece

[13] Univ Toulouse, Unite Genom Myelome, Toulouse, France

[14] Ctr Hematol Oncol & Palliat Care, Clin Ottakring, Dept Med 1, Vienna, Austria

[15] Sorbonne Univ, Hosp St Antoine, Dept Clin Hematol & Cellular Therapy, Paris, France

[16] Univ Hosp Salamanca, Canc Res Ctr, IBSAL, Salamanca, Spain

[17] Univ Hosp Wurzburg, Dept Internal Med 2, Wurzburg, Germany

[18] UZ Leuven, Dept Hematol, Leuven, Belgium

[19] CHU Liege, Dept Clin Hematol, Liege, Belgium

[20] Univ Klinikum Hamburg Eppendorf, Med Klin & Poliklin 2, Hamburg, Germany

[21] Newcastle Upon Tyne Hosp Trust, NCCC, Newcastle Upon Tyne, Tyne & Wear, England

[22] Sorbonne Univ, Hop Pitie Salpetriere, AP HP,INSERM,UMR S 938,Serv Hematol, Ctr Rech St Antoine Team Proliferat & Differentia, Paris, France

[23] Univ Freiburg, Fac Freiburg, Interdisciplinary Tumor Ctr, Freiburg, Germany

[24] Univ Poitiers Hosp, Poitiers, France

[25] Univ Hosp Heidelberg, Internal Med 5, Heidelberg, Germany

[26] Univ Hosp Heidelberg, Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[27] Ankara Univ, Dept Hematol, Ankara, Turkey

[28] Univ Southern Denmark, Odense Univ Hosp, Dept Hematol, Odense, Denmark

[29] Erasmus Univ, Erasmus MC Canc Inst, Rotterdam, Netherlands

来源：

LEUKEMIA | 2021年 / 35卷 / 01期

关键词：

STEM-CELL TRANSPLANTATION; HEPATITIS-B-VIRUS; INFLUENZAE TYPE-B; PNEUMOCOCCAL CONJUGATE VACCINE; MONOCLONAL GAMMOPATHY; UNDETERMINED SIGNIFICANCE; HEMATOLOGIC MALIGNANCIES; HUMORAL IMMUNITY; CANCER-PATIENTS; DISEASE;

D O I：

10.1038/s41375-020-01016-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vaccination is one of the most successful medical interventions that has saved the life of millions of people. Vaccination is particularly important in patients with multiple myeloma, who have an increased risk of infections due to the disease-inherent immune suppression, and because of the immune suppressive effects of therapy. Hence, all appropriate measures should be exploited, to elicit an effective immune response to common pathogens like influenza, pneumococci, varicella zoster virus, and to those bacteria and viruses (haemophilus influenzae, meningococci, and hepatitis) that frequently may pose a significant risk to patients with multiple myeloma. Patients after autologous, and specifically after allogeneic transplantation have severely reduced antibody titers, and therefore require a broader spectrum of vaccinations. Response to vaccination in myeloma often is less vigorous than in the general population, mandating either measurement of the postvaccination antibody titers and/or repeating the vaccination. Here, we compile the existing data on vaccination in multiple myeloma and provide recommendations for clinical practice.

引用

页码：31 / 44

页数：14

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