Possible interaction between cisapride and bromperidol

被引：5
|
作者：
Ishida, M
Otani, K
Yasui, N
Inoue, Y
Kaneko, S
机构：
[1] HIROSAKI UNIV HOSP, DEPT NEUROPSYCHIAT, HIROSAKI, AOMORI 036, JAPAN
[2] YOSHITOMI PHARMACEUT IND LTD, PHARMACEUT TECHNOL CTR, FUKUOKA, JAPAN
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1997年 / 21卷 / 01期
关键词：
bromperidol; cisapride; interaction; plasma concentration; schizophrenia;
D O I：
10.1016/S0278-5846(96)00165-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1.The case of a schizophrenic patient taking bromperidol (18 mg/day), whose psychotic symptoms deteriorated markedly after addition of cisapride (7.5 mg/day), is presented. 2.Retrospective determination of drug concentrations revealed that plasma concentrations of bromperidol and its reduced metabolite were increased after cisapride addition. 3.The present study thus suggests that there is an interaction between cisapride and bromperidol.
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页码：235 / 238
页数：4
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