Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk:: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)

被引：41

作者：

Dossus, Laure ^{[1
]}

Mckay, James D. ^{[2
]}

Canzian, Federico ^{[1
]}

Wilkening, Stefan ^{[1
]}

Rinaldi, Sabina ^{[3
]}

Biessy, Carine ^{[3
]}

Olsen, Anja ^{[4
]}

Tjonneland, Anne ^{[4
]}

Jakobsen, Marianne U. ^{[5
]}

Overvad, Kim ^{[5
]}

Clavel-Chapelon, Francoise ^{[6
,7
]}

Boutron-Ruault, Marie-Christine ^{[6
,7
]}

Fournier, Agnes ^{[6
,7
]}

Linseisen, Jakob ^{[1
]}

Lukanova, Annekatrin ^{[1
]}

Boeing, Heiner ^{[8
]}

Fisher, Eva ^{[8
]}

Trichopoulou, Antonia ^{[9
]}

Georgila, Christina ^{[9
]}

Trichopoulos, Dimitrios ^{[10
,11
]}

Palli, Domenico ^{[12
]}

Krogh, Vittorio ^{[13
]}

Tumino, Rosario ^{[14
]}

Vineis, Paolo ^{[15
]}

Quiros, Jose Ramon ^{[16
]}

Sala, Nuria ^{[17
]}

Martinez-Garcia, Carmen ^{[18
]}

Dorronsoro, Miren ^{[19
]}

Chirlaque, Maria-Dolores ^{[20
]}

Barricarte, Aurelio ^{[21
]}

van Duijnhoven, Franzel J. B. ^{[22
]}

Bueno-de-Mesquita, H. B. ^{[22
]}

van Gils, Carla H. ^{[23
]}

Peeters, Petra H. M. ^{[23
]}

Hallmans, Goran ^{[24
]}

Lenner, Per ^{[25
]}

Bingham, Sheila ^{[26
,27
]}

Khaw, Kay Tee ^{[28
]}

Key, Tim J. ^{[29
]}

Travis, Ruth C. ^{[29
]}

Ferrari, Pietro ^{[3
]}

Jenab, Mazda ^{[3
]}

Riboli, Elio ^{[15
]}

Kaaks, Rudolf ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[2] Int Agcy Res Canc, Genet Epidemiol Grp, F-69372 Lyon, France

[3] Int Agcy Res Canc, Epidemiol Methods & Support Grp, F-69372 Lyon, France

[4] Danish Canc Soc, Inst Canc Epidemiol, Dept Diet Canc & Hlth, DK-2100 Copenhagen, Denmark

[5] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark

[6] INSERM, Dept Epidemiol & Publ Hlth, ERI 20, EA 4045, F-94805 Villejuif, France

[7] Inst Gustave Roussy, F-94805 Villejuif, France

[8] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, D-14558 Nuthetal, Germany

[9] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece

[10] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[11] Hellenic Hlth Fdn, Athens 11527, Greece

[12] Sci Inst Tuscany, Ctr Canc Res & Prevent, Mol & Nutr Epidemiol Unit, I-50139 Florence, Italy

[13] Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, Italy

[14] Azienda Osped Civile MP Arezzo, Canc Registry, I-97100 Ragusa, Italy

[15] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London SW7, England

[16] Publ Hlth & Hlth Planning Directorate, Asturias Oviedo 33001, Spain

[17] Hosp Llobregat, Barcelona Inst Invest Biomed Bellvitge, Catalan Inst Oncol, Dept Epidemiol,Lab Recerca Translac, Barcelona 08907, Spain

[18] CIBER Epidemil & Salud Publ, Andalusian Sch Publ Hlth, Granada 18011, Spain

[19] Dept Publ Hlth Guipuzkoa, San Sebastian 20013, Donostia San Se, Spain

[20] CIBER Epidemiol & Salud Publ CIBERESP, Murcia Hlth Council, Dept Epidemiol, Murcia Granade 18011, Spain

[21] CIBERESP, Publ Hlth Inst Navarra, Pamplona 31003, Spain

[22] Natl Inst Publ Hlth & Environm, Ctr Nutr & Hlth, NL-3720 BA Bilthoven, Netherlands

[23] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands

[24] Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden

[25] Umea Univ, Dept Radiat Sci, S-90187 Umea, Sweden

[26] MRC Dunn Human Nutr Unit, Cambridge CB2 0XY, England

[27] Univ Cambridge, Dept Publ Hlth & Primary Care, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge CB1 8RN, England

[28] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England

[29] Univ Oxford, Epidemiol Unit, Oxford OX3 7XP, England

来源：

CARCINOGENESIS | 2008年 / 29卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/carcin/bgn083

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also suggests a role of ghrelin in cancer development. We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. Pair-wise tagging was used to select the 15 polymorphisms that represent the majority of common genetic variants across the GHRL and GHSR genes. A significant increase in breast cancer risk was observed in carriers of the GHRL rs171407-G allele (odds ratio: 1.2; 95% confidence interval: 1.0-1.4; P = 0.02). The GHRL single-nucleotide polymorphism rs375577 was associated with a 5% increase in IGF-I levels (P = 0.01). A number of GHRL and GHSR polymorphisms were associated with body mass index (BMI) and height (P between < 0.01 and 0.04). The false-positive report probability (FPRP) approach suggests that these results are noteworthy (FPRP < 0.20). The results presented here add to a growing body of evidence that GHRL variations are associated with BMI. Furthermore, we have observed evidence for association of GHRL polymorphisms with circulating IGF-I levels and with breast cancer risk. These associations, however, might also be due to chance findings and further large studies are needed to confirm our results.

引用

页码：1360 / 1366

页数：7

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