Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression

被引:76
作者
Koike, Hiroyuki [1 ]
Fukumoto, Kenichi [1 ]
Iijima, Michihiko [1 ]
Chaki, Shigeyuki [1 ]
机构
[1] Taisho Pharmaceut Co Ltd, Mol Funct & Pharmacol Labs, Discovery Pharmacol 1, Kita Ku, Saitama 3319530, Japan
关键词
BDNF; mGlu2/3 receptor antagonist; Novelty-suppressed feeding test; Tail suspension test; TrkB; METHYL-D-ASPARTATE; TAIL SUSPENSION TEST; NEUROTROPHIC FACTOR; PREFRONTAL CORTEX; AMPA RECEPTOR; EXTRACELLULAR GLUTAMATE; BEHAVIORAL-MODELS; SUICIDE VICTIMS; KETAMINE; INVOLVEMENT;
D O I
10.1016/j.bbr.2012.10.023
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
We previously revealed that the activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor and mammalian target of rapamycin signaling contributed to the antidepressant-like effects of group II metabotropic glutamate (mGlu2/3) receptor antagonists, suggesting that the signaling pathway may be similar to the molecular mechanisms underlying the antidepressant-like action of ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist that exertes rapid and sustained antidepressant effects in patients with depressive disorder. Although brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signaling reportedly participates in the antidepressant-like effects of ketamine, the involvement of BDNF/TrkB signaling in the action of mGlu2/3 receptor antagonists has not been investigated. We therefore examined whether the activation of BDNF/TrkB signaling is required for the antidepressant-like effects of LY341495, an mGlu2/3 receptor antagonist, in animal models of depression such as the tail suspension test (TST) and the novelty-suppressed feeding test (NSFT). The administration of LY341495 at 30 min prior to the test exerted antidepressant-like effects (acute effects) lasting for at least 24 h (sustained effects) when evaluated using the TST and NSFT. Pretreatment with K252a, a TrkB tyrosine kinase inhibitor, blocked the sustained, but not the acute, effects of LY341495. These results suggest that BDNF/TrkB signaling may be involved in the sustained antidepressant-like effects of LY341495, as observed for ketamine treatment. (c) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:48 / 52
页数:5
相关论文
共 47 条
[1]   NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses [J].
Autry, Anita E. ;
Adachi, Megunai ;
Nosyreva, Elena ;
Na, Elisa S. ;
Los, Maarten F. ;
Cheng, Peng-fei ;
Kavalali, Ege T. ;
Monteggia, Lisa M. .
NATURE, 2011, 475 (7354) :91-U109
[2]   Antidepressant effects of ketamine in depressed patients [J].
Berman, RM ;
Cappiello, A ;
Anand, A ;
Oren, DA ;
Heninger, GR ;
Charney, DS ;
Krystal, JH .
BIOLOGICAL PSYCHIATRY, 2000, 47 (04) :351-354
[3]   MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity [J].
Chaki, S ;
Yoshikawa, R ;
Hirota, S ;
Shimazaki, T ;
Maeda, M ;
Kawashima, N ;
Yoshimizu, T ;
Yasuhara, A ;
Sakagami, K ;
Okuyama, S ;
Nakanishi, S ;
Nakazato, A .
NEUROPHARMACOLOGY, 2004, 46 (04) :457-467
[4]  
Chaki S., NEUROPHARMA IN PRESS
[5]   The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice [J].
Cryan, JF ;
Mombereau, C ;
Vassout, A .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 29 (4-5) :571-625
[6]   A simple role for BDNF in learning and memory? [J].
Cunha, Carla ;
Brambilla, Riccardo ;
Thomas, Kerrie L. .
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2010, 3
[7]   A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression [J].
Diazgranados, Nancy ;
Ibrahim, Lobna ;
Brutsche, Nancy E. ;
Newberg, Andrew ;
Kronstein, Phillip ;
Khalife, Sami ;
Kammerer, William A. ;
Quezado, Zenaide ;
Luckenbaugh, David A. ;
Salvadore, Giacomo ;
Machado-Vieira, Rodrigo ;
Manji, Husseini K. ;
Zarate, Carlos A., Jr. .
ARCHIVES OF GENERAL PSYCHIATRY, 2010, 67 (08) :793-802
[8]  
Duncan WC, 2012, INT J NEUROPSYCHOPHA
[9]   Modulation in Activation and Expression of Phosphatase and Tensin Homolog on Chromosome Ten, Akt1, and 3-Phosphoinositide-Dependent Kinase 1: Further Evidence Demonstrating Altered Phosphoinositide 3-Kinase Signaling in Postmortem Brain of Suicide Subjects [J].
Dwivedi, Yogesh ;
Rizavi, Hooriyah S. ;
Zhang, Hui ;
Roberts, Rosalinda C. ;
Conley, Robert R. ;
Pandey, Ghanshyam N. .
BIOLOGICAL PSYCHIATRY, 2010, 67 (11) :1017-1025
[10]   mTOR activation is required for the antidepressant effects of mGluR2/3 blockade [J].
Dwyer, Jason M. ;
Lepack, Ashley E. ;
Duman, Ronald S. .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2012, 15 (04) :429-434