Cytosystems dynamics in self-organization of tissue architecture

被引:351
作者
Sasai, Yoshiki [1 ]
机构
[1] RIKEN, Ctr Dev Biol, Neurogenesis & Organogenesis Grp, Kobe, Hyogo 6500047, Japan
关键词
BRANCHING MORPHOGENESIS; PATTERN-FORMATION; CELL MORPHOLOGY; STEM-CELLS; IN-VITRO; GROWTH; REGENERATION; RECONSTRUCTION; EMBRYOS; MODEL;
D O I
10.1038/nature11859
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Our knowledge of the principles by which organ architecture develops through complex collective cell behaviours is still limited. Recent work has shown that the shape of such complex tissues as the optic cup forms by self-organization in vitro from a homogeneous population of stem cells. Multicellular self-organization involves three basic processes that are crucial for the emergence of latent intrinsic order. Based on lessons from recent studies, cytosystems dynamics is proposed as a strategy for understanding collective multicellular behaviours, incorporating four-dimensional measurement, theoretical modelling and experimental reconstitution.
引用
收藏
页码:318 / 326
页数:9
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