Neuromodulation for Brain Disorders: Challenges and Opportunities

被引：176

作者：

Johnson, Matthew D. ^{[1
]}

Lim, Hubert H. ^{[1
]}

Netoff, Theoden I. ^{[1
]}

Connolly, Allison T. ^{[1
]}

Johnson, Nessa ^{[1
]}

Roy, Abhrajeet ^{[1
]}

Holt, Abbey ^{[2
]}

Lim, Kelvin O. ^{[3
]}

Carey, James R. ^{[4
]}

Vitek, Jerrold L. ^{[5
]}

He, Bin ^{[1
,6
]}

机构：

[1] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Phys Therapy Program, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA

[6] Univ Minnesota, Inst Engn Med, Minneapolis, MN 55455 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2013年 / 60卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Deep brain stimulation (DBS); intracranial cortical stimulation (ICS); neuroengineering; neuromodulation; transcranial direct current stimulation (tDCS); transcranial magnetic stimulation (TMS); TRANSCRANIAL MAGNETIC STIMULATION; HIGH-FREQUENCY STIMULATION; MOTOR CORTEX STIMULATION; ELECTRICAL-STIMULATION; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; PREFRONTAL CORTEX; CORTICAL STIMULATION; CONTROLLED TRIAL; AUDITORY-CORTEX;

D O I：

10.1109/TBME.2013.2244890

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapies including deep brain stimulation, intracranial cortical stimulation, transcranial direct current stimulation, and transcranial magnetic stimulation have all shown promising results across a range of neurological and neuropsychiatric disorders. While the mechanisms of therapeutic action are invariably different among these approaches, there are several fundamental neuroengineering challenges that are commonly applicable to improving neuromodulation efficacy. This paper reviews the state-of-the-art of neuromodulation for brain disorders and discusses the challenges and opportunities available for clinicians and researchers interested in advancing neuromodulation therapies.

引用

页码：610 / 624

页数：15

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