Neuromodulation for Brain Disorders: Challenges and Opportunities

被引：159
作者：
Johnson, Matthew D. [1 ]
Lim, Hubert H. [1 ]
Netoff, Theoden I. [1 ]
Connolly, Allison T. [1 ]
Johnson, Nessa [1 ]
Roy, Abhrajeet [1 ]
Holt, Abbey [2 ]
Lim, Kelvin O. [3 ]
Carey, James R. [4 ]
Vitek, Jerrold L. [5 ]
He, Bin [1 ,6 ]
机构：
[1] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
[4] Univ Minnesota, Phys Therapy Program, Minneapolis, MN 55455 USA
[5] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA
[6] Univ Minnesota, Inst Engn Med, Minneapolis, MN 55455 USA
来源：
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2013年 / 60卷 / 03期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Deep brain stimulation (DBS); intracranial cortical stimulation (ICS); neuroengineering; neuromodulation; transcranial direct current stimulation (tDCS); transcranial magnetic stimulation (TMS); TRANSCRANIAL MAGNETIC STIMULATION; HIGH-FREQUENCY STIMULATION; MOTOR CORTEX STIMULATION; ELECTRICAL-STIMULATION; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; PREFRONTAL CORTEX; CORTICAL STIMULATION; CONTROLLED TRIAL; AUDITORY-CORTEX;
D O I：
10.1109/TBME.2013.2244890
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapies including deep brain stimulation, intracranial cortical stimulation, transcranial direct current stimulation, and transcranial magnetic stimulation have all shown promising results across a range of neurological and neuropsychiatric disorders. While the mechanisms of therapeutic action are invariably different among these approaches, there are several fundamental neuroengineering challenges that are commonly applicable to improving neuromodulation efficacy. This paper reviews the state-of-the-art of neuromodulation for brain disorders and discusses the challenges and opportunities available for clinicians and researchers interested in advancing neuromodulation therapies.
引用
收藏
页码：610 / 624
页数：15
相关论文
共 137 条
  • [11] Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro
    Bikson, M
    Inoue, M
    Akiyama, H
    Deans, JK
    Fox, JE
    Miyakawa, H
    Jefferys, JGR
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2004, 557 (01): : 175 - 190
  • [12] Current focusing and steering: Modeling, physiology, and psychophysics
    Bonham, Ben H.
    Litvak, Leonid M.
    [J]. HEARING RESEARCH, 2008, 242 (1-2) : 141 - 153
  • [13] High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey
    Boraud, T
    Bezard, E
    Bioulac, B
    Gross, C
    [J]. NEUROSCIENCE LETTERS, 1996, 215 (01) : 17 - 20
  • [14] Examining Transcranial Direct-Current Stimulation (tDCS) as a Treatment for Hallucinations in Schizophrenia
    Brunelin, Jerome
    Mondino, Marine
    Gassab, Leila
    Haesebaert, Frederic
    Gaha, Lofti
    Suaud-Chagny, Marie-Francoise
    Saoud, Mohamed
    Mechri, Anwar
    Poulet, Emmanuel
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2012, 169 (07) : 719 - 724
  • [15] Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions
    Brunoni, Andre Russowsky
    Nitsche, Michael A.
    Bolognini, Nadia
    Bikson, Marom
    Wagner, Tim
    Merabet, Lotfi
    Edwards, Dylan J.
    Valero-Cabre, Antoni
    Rotenberg, Alexander
    Pascual-Leone, Alvaro
    Ferrucci, Roberta
    Priori, Alberto
    Boggio, Paulo Sergio
    Fregni, Felipe
    [J]. BRAIN STIMULATION, 2012, 5 (03) : 175 - 195
  • [16] A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation
    Brunoni, Andre Russowsky
    Amadera, Joao
    Berbel, Bruna
    Volz, Magdalena Sarah
    Rizzerio, Brenno Gomes
    Fregni, Felipe
    [J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2011, 14 (08) : 1133 - 1145
  • [17] Patient-speciftic analysis of the volume of tissue activated during deep brain stimulation
    Butson, Christopher R.
    Cooper, Scott E.
    Henderson, Jaimie M.
    McIntyre, Cameron C.
    [J]. NEUROIMAGE, 2007, 34 (02) : 661 - 670
  • [18] MODULATION BY APPLIED ELECTRIC-FIELDS OF PURKINJE AND STELLATE CELL-ACTIVITY IN THE ISOLATED TURTLE CEREBELLUM
    CHAN, CY
    NICHOLSON, C
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1986, 371 : 89 - 114
  • [19] LONG-TERM EFFECTS OF rTMS ON MOTOR RECOVERY IN PATIENTS AFTER SUBACUTE STROKE
    Chang, Won Hyuk
    Kim, Yun-Hee
    Bang, Oh Young
    Kim, Sung Tae
    Park, Yun H.
    Lee, Peter K. W.
    [J]. JOURNAL OF REHABILITATION MEDICINE, 2010, 42 (08) : 758 - 764
  • [20] A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS
    Cheeran, Binith
    Talelli, Penelope
    Mori, Francesco
    Koch, Giacomo
    Suppa, Antonio
    Edwards, Mark
    Houlden, Henry
    Bhatia, Kailash
    Greenwood, Richard
    Rothwell, John C.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (23): : 5717 - 5725
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