The role of Qishen Yiqi dripping pills in treating chronic heart failure: An overview of systematic reviews and meta-analyses

被引:4
作者
Chen, Wensheng [1 ]
Chen, Jiezhen [1 ]
Wang, Yuanping [2 ]
Yan, Jiaqi [1 ]
Yan, Xia [1 ]
Wang, Dawei [2 ,3 ]
Liu, Yuntao [1 ]
机构
[1] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China
[2] Guangzhou Univ Chinese Med, Shunde Hosp, Guangzhou, Peoples R China
[3] Univ Chinese Med, Clin Med Coll Guangzhou 1, Guangzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
Qishen Yiqi drop pill; chronic heart failure; systematic review; meta-analyses; overview; TRADITIONAL CHINESE MEDICINE; DISEASE; TRIALS;
D O I
10.3389/fcvm.2022.1001072
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Evidence from systematic reviews/meta-analyses about the efficacy and safety of Qishen Yiqi (QSYQ) dripping pills in chronic heart failure (CHF) remains unclear. This study comprehensively reviewed available systematic reviews on latest evidence to provide reliable information for the clinical use of QSYQ in CHF. Methods: The systematic review was performed on studies retrieved from six major medical databases. Eligible studies were evaluated in terms of methodological quality and quality of evidence using the Assessment of Multiple Systematic review 2 (AMSTAR-2) tool, the Risk of Bias in Systematic Reviews (ROBIS) was used to assess the risk of bias, and the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) 2020 was utilized for assessing reporting quality. In addition, the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to determine primary outcome indicators' evidence quality. Results: A total of 14 systematic reviews were included in this study, based on which it could be concluded that QSYQ combined with conventional medicine (CM) treatment tended to be superior to CM treatment alone in terms of improving cardiac function-related indices (e.g., increasing the left ventricular ejection fraction [LVEF] and reducing the left ventricular end-diastolic dimension [LVEDD] and left ventricular end-systolic internal diameter [LVESD]), improving the total effective rate and 6-min walking distance (6MWD), and reducing N-terminal pro-brain natriuretic peptide (NT-proBNP). Overall, no serious QSYQ-related adverse events were observed. However, the GRADE results showed "very low " to "moderate " evidence for these outcomes, with no high-quality evidence supporting them. Unsatisfactory results were obtained in terms of methodological quality, risk of bias and reporting quality after assessment using the AMSTAR-2, ROBIS, and PRISMA 2020, limited mainly by deficiencies in the following areas: registration of study protocols, explanation of the inclusion of randomized controlled trials (RCTs), complete and detailed search strategy, list of excluded literature, description of funding sources for inclusion in RCTs, investigation of the impact of risk of bias on the results of meta-analysis, and reporting of potential conflicts of interest. Conclusion: The efficacy and safety of QSYQ adjuvant therapy in CHF remain to be further clarified due to the lack of high-quality evidence provided by current systematic reviews.
引用
收藏
页数:18
相关论文
共 49 条
[1]   The Global Health and Economic Burden of Hospitalizations for Heart Failure Lessons Learned From Hospitalized Heart Failure Registries [J].
Ambrosy, Andrew P. ;
Fonarow, Gregg C. ;
Butler, Javed ;
Chioncel, Ovidiu ;
Greene, Stephen J. ;
Vaduganathan, Muthiah ;
Nodari, Savina ;
Lam, Carolyn S. P. ;
Sato, Naoki ;
Shah, Ami N. ;
Gheorghiade, Mihai .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (12) :1123-1133
[3]   GRADE guidelines: 3. Rating the quality of evidence [J].
Balshem, Howard ;
Helfand, Mark ;
Schuenemann, Holger J. ;
Oxman, Andrew D. ;
Kunz, Regina ;
Brozek, Jan ;
Vist, Gunn E. ;
Falck-Ytter, Yngve ;
Meerpohl, Joerg ;
Norris, Susan ;
Guyatt, Gordon H. .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2011, 64 (04) :401-406
[4]   Searching for qualitative research for inclusion in systematic reviews: A structured methodological review [J].
Booth A. .
Systematic Reviews, 5 (1)
[5]   Clinical Efficacy and Safety of Qishen Yiqi Dropping Pill Combined with Conventional Western Medicine in the Treatment of Chronic Heart Failure: A Systematic Review and Meta-Analysis [J].
Chen, Lisheng ;
Wang, Ruilin ;
Liu, Honghong ;
Wei, Shizhang ;
Jing, Manyi ;
Wang, Min ;
Zhao, Yanling .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2021, 2021
[6]  
Cheng CW, 2017, ANN INTERN MED, V167, P112, DOI [10.7326/M16-2977, 10.7326/IsTranslatedFrom_M17-2977_1, 10.7326/IsTranslatedFrom_M17-2977_2]
[7]   Defining heart failure [J].
Coronel, R ;
de Groot, JR ;
van Lieshout, JJ .
CARDIOVASCULAR RESEARCH, 2001, 50 (03) :419-422
[8]  
Editorial Board of Chinese Journal of Cardiology, 2014, ZHONGHUA XIN XUE GUA, V42, P98
[9]  
[樊根豪 Fan Genhao], 2020, [中国中医基础医学杂志, Chinese Journal of Basic Medicine in Traditional Chinese Medicine], V26, P932
[10]   Endpoints in Heart Failure Drug Development History and Future [J].
Fiuzat, Mona ;
Lowy, Naomi ;
Stockbridge, Norman ;
Sbolli, Marco ;
Latta, Federica ;
Lindenfeld, JoAnn ;
Lewis, Eldrin F. ;
Abraham, William T. ;
Teerlink, John ;
Walsh, Mary ;
Heidenreich, Paul ;
Bozkurt, Biykem ;
Starling, Randall C. ;
Solomon, Scott ;
Felker, G. Michael ;
Butler, Javed ;
Yancy, Clyde ;
Stevenson, Lynne W. ;
O'Connor, Christopher ;
Unger, Ellis ;
Temple, Robert ;
McMurray, John .
JACC-HEART FAILURE, 2020, 8 (06) :429-440