Advances in Therapeutic Approaches for Spontaneous Intracerebral Hemorrhage

被引:65
作者
Al-Kawaz, Mais N. [1 ]
Hanley, Daniel F. [1 ]
Ziai, Wendy [1 ]
机构
[1] Johns Hopkins Univ Hosp, 1800 Orleans St,Phipps 455, Baltimore, MD 21287 USA
基金
美国国家卫生研究院;
关键词
Intracerebral hemorrhage; Intraventricular hemorrhage; Stroke; Outcomes; Fibrinolysis; MINIMALLY INVASIVE SURGERY; PROTHROMBIN COMPLEX CONCENTRATE; BLOOD-PRESSURE REDUCTION; INITIAL CONSERVATIVE TREATMENT; SEVERE VENTRICULAR INVOLVEMENT; DECOMPRESSIVE HEMICRANIECTOMY; INTRAVENTRICULAR HEMORRHAGE; PERIHEMATOMAL EDEMA; OPEN-LABEL; ANTIPLATELET THERAPY;
D O I
10.1007/s13311-020-00902-w
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Spontaneous intracerebral hemorrhage (ICH) results in high rates of morbidity and mortality, with intraventricular hemorrhage (IVH) being associated with even worse outcomes. Therapeutic interventions in acute ICH have continued to emerge with focus on arresting hemorrhage expansion, clot volume reduction of both intraventricular and parenchymal hematomas, and targeting perihematomal edema and inflammation. Large randomized controlled trials addressing the effectiveness of rapid blood pressure lowering, hemostatic therapy with platelet transfusion, and other clotting complexes and hematoma volume reduction using minimally invasive techniques have impacted clinical guidelines. We review the recent evolution in the management of acute spontaneous ICH, discussing which interventions have been shown to be safe and which may potentially improve outcomes.
引用
收藏
页码:1757 / 1767
页数:11
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