Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons

被引:147
作者
Cembrowski, Mark S. [1 ]
Spruston, Nelson [1 ]
机构
[1] Janelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
关键词
DORSAL-VENTRAL AXIS; PROXIMODISTAL AXIS; ENTORHINAL CORTEX; GENE-EXPRESSION; DENTATE GYRUS; PHYSIOLOGICAL-PROPERTIES; SPATIAL REPRESENTATION; NONSPATIAL INFORMATION; LAMINAR ORGANIZATION; FUNCTIONAL DIVERSITY;
D O I
10.1038/s41583-019-0125-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The mechanistic operation of brain regions is often interpreted by partitioning constituent neurons into 'cell types'. Historically, such cell types were broadly defined by their correspondence to gross features of the nervous system (such as cytoarchitecture). Modern-day neuroscientific techniques, enabling a more nuanced examination of neuronal properties, have illustrated a wealth of heterogeneity within these classical cell types. Here, we review the extent of this within-cell-type heterogeneity in one of the simplest cortical regions of the mammalian brain, the rodent hippocampus. We focus on the mounting evidence that the classical CA3, CA1 and subiculum pyramidal cell types all exhibit prominent and spatially patterned within-cell-type heterogeneity, and suggest these cell types provide a model system for exploring the organization and function of such heterogeneity. Given that the hippocampus is structurally simple and evolutionarily ancient, within-cell-type heterogeneity is likely to be a general and crucial feature of the mammalian brain.
引用
收藏
页码:193 / 204
页数:12
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