Febuxostat: A Novel Agent for Management of Hyperuricemia in Gout

被引：14

作者：

Bisht, Manisha ^{[1
]}

Bist, S. S. ^{[1
]}

机构：

[1] HIHT Univ, Himalayan Inst Med Sci, Dept Pharmacol & ENT, Dehra Dun 248140, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2011年 / 73卷 / 06期

关键词：

Gout; hyperuricemia; xanthine oxidase inhibitor; XANTHINE OXIDASE/XANTHINE DEHYDROGENASE; PURINE SELECTIVE INHIBITOR; PHASE-III; JAPANESE SUBJECTS; CLINICAL-TRIAL; DOUBLE-BLIND; SERUM URATE; ALLOPURINOL; OXIDASE; PLACEBO;

D O I：

10.4103/0250-474X.100231

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gout is a metabolic disorder characterized by elevated uric acid levels in the body, associated with painful arthritis, tophi and nephropathy. The most frequently used pharmacologic urate lowering strategies involve reducing urate production with a xanthine oxidase inhibitor and enhancing urinary excretion of uric acid with a uricosuric agent. Urate lowering agents are limited in number, availability and effectiveness. The emergence of a new medication, febuxostat, to lower serum urate levels is welcome as no new drug have been approved since the introduction of allopurinol, in 1964, and the drugs that are available have limitations owing to inefficacy or toxicity. Febuxostat is a novel, nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for patients with hyperuricemia and gout.

引用

页码：597 / 600

页数：4

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