Gold Nanoparticles Decorated Liposomes and Their SERS Performance in Tumor Cells

被引：2

作者：

Zhu, D. ^{[1
]}

Wang, Z. Y. ^{[1
]}

Zong, S. F. ^{[1
]}

Chen, H. ^{[1
]}

Chen, P. ^{[1
]}

Li, M. Y. ^{[1
]}

Wu, L. ^{[1
]}

Cui, Y. P. ^{[1
]}

机构：

[1] Southeast Univ, Adv Photon Ctr, Nanjing 210096, Jiangsu, Peoples R China

来源：

THIRD INTERNATIONAL SYMPOSIUM ON LASER INTERACTION WITH MATTER | 2015年 / 9543卷

关键词：

liposome; gold nanoparticles; hybrid; tumor cells; SERS; DRUG-DELIVERY SYSTEMS; CLINICAL DEVELOPMENT; BILAYER; SIZE;

D O I：

10.1117/12.2182146

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Due to their unique properties, liposomes have been widely used as drug nanocarriers. Herein a liposome-Au nanohybrid has been demonstrated as a SERS active intracellular drug nanocarrier. In this study, cationic Raman reporter tagged gold nanoparticles (Au@4MBA@PAH) were anchored onto the surfaces of anionic liposomes via electrostatic interactions. Using SKBR3 cells as model cells, we revealed that the hybrid formulation can be effectively taken up by tumor cells and tracked by the SERS signals. Collectively, the liposome-Au nanohybrids hold great promise in biomedical applications.

引用

页数：6

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