Interactions Among Regulatory Non-coding RNAs Involved in Cardiovascular Diseases

被引：11

作者：

Gabriel, Andre F. ^{[1
,2
]}

Costa, Marina C. ^{[1
,2
]}

Enguita, Francisco J. ^{[1
,2
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal

[2] Univ Lisbon, Fac Med, Cardi Unit, CCUL, Lisbon, Portugal

来源：

NON-CODING RNAS IN CARDIOVASCULAR DISEASES | 2020年 / 1229卷

关键词：

Long noncoding RNA; Circular RNA; microRNA; Interaction and cardiovascular disease; RNA-regulatory networks; Competing endogenous RNA; ACUTE MYOCARDIAL-INFARCTION; COMPETING ENDOGENOUS RNA; HYPOXIA-INDUCED INJURY; PROTECTS H9C2 CELLS; CIRCULAR RNA; CARDIAC-HYPERTROPHY; ISCHEMIA/REPERFUSION INJURY; PROGRAMMED NECROSIS; UP-REGULATION; APOPTOSIS;

D O I：

10.1007/978-981-15-1671-9_4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-coding RNAs (ncRNAs) are important regulatory players in human cells that have been shown to modulate different cellular processes and biological functions through controlling gene expression, being also involved in pathological conditions such as cardiovascular diseases. Among them, long non-coding RNAs (lncRNAs) and circular (circRNAs) could act as competing endogenous RNAs (ceRNAs) sequestering other ncRNAs. This entangled network of interactions has been reported to trigger the decay of the targeted ncRNAs having important roles in gene regulation. Growing evidences have been demonstrated that the regulatory mechanism underlying the crosstalk between different ncRNA species, namely lncRNAs, circRNAs and miRNAs has also an important role in the pathophysiological processes of cardiovascular diseases. In this chapter, the main regulatory relationship among lncRNAs, circRNAs and miRNAs were summarized and their role in the control and development of cardiovascular diseases was highlighted.

引用

页码：79 / 104

页数：26

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